MicroRNA as a Therapeutic Target in Cardiac Remodeling

Table 5

Summary of reported miRNAs and their targets in Inflammatory Response.

miRNAs	Targets	Regulation factors	References
MiR-155	SOCS1, SHIP1, IL-13Ra1	IFN-b, TNF-a, IL-1	[141–146]
miR-125a	TNFAIP3 (A20)	LPS	[147]
miR-125b	TNFAIP3, TNF-a	LPS	[123, 147]
miR-125a-5p	TLR2, TLR4	LPS	[148]
miR-21	CSF-1R	LPS	[149]
miR-22	Rasa1, Nfat5	PPARg	[150]
miR-27a	PPARg	M-CSF	[151]
Mir-375	PDK1	M-CSF	[152]
MiR-126	ADAM9	LPS	[153]
MiR-145-5p	CD40	IL-1β, TNF-α, IL-6	[154]
MiR-146a	IRAK, TRAF6	LPS, TNF-α	[155]

SOCS1: suppressor of cytokine signaling 1; SHIP1: inositol polyphosphate-5-phosphatase D; TNF-a: tumor necrosis factor a; LPS: lipopolysaccharides; CSF-1R: colony stimulating factor 1 receptor; Rasa1: RAS p21 protein activator 1; Nfat5: nuclear factor of activated T-cells 5; PDK1: pyruvate dehydrogenase kinase 1; IRAK: interleukin 1 receptor associated kinase; TRAF6: TNF receptor associated factor 6; ADAM9: A disintegrin and metalloproteinase 9.