Pentoxifylline Regulates Plasminogen Activator Inhibitor-1 Expression and Protein Kinase A Phosphorylation in Radiation-Induced Lung Fibrosis

Figure 1

Evaluation of radiation-induced lung fibrosis. (a) Manifestation of RILF in nonirradiated or irradiated rats before irradiation (IR) or until 16 weeks after IR. Fibrosis-related findings such as increased lung density and volume loss were detected since 12 weeks after IR, and severe right deviation of heart was seen after 16 weeks of IR. (b–d) Lung density (b), lung area (c), and cardiac right-lateral shift (d) of control (Cont) and irradiated (IR) rats at the indicated times before (0 w) and after irradiation. Data are expressed as the mean ± standard error of the mean (SEM) . versus control group. (e) Representative images of H&E stained sections of lung tissue of before (0 w) and after 8, 12, and 16 weeks after irradiation. Scale bar (right bottom) represents 200 µm. Micro-CT, micro-computed tomography; RILF, radiation-induced lung fibrosis; HU, Hounsfield units; w, weeks.

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