Drug Target Protein-Protein Interaction Networks: A Systematic Perspective

Figure 9

17-core subnetwork of the drug targets PPI network. As shown in four ego networks of the known drug targets (PSMD1, TOP2A) and normal proteins (EWSR1, ATXN1), the neighbors of a drug target are less but those neighbors have higher degree than normal proteins. It implies a very important drug protein’s reaction mechanism, that is, the drug target protein’s interaction with most high connective proteins, though few of them are the hubs as important bridges of the PPI network.