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BioMed Research International
Volume 2017 (2017), Article ID 1295038, 6 pages
https://doi.org/10.1155/2017/1295038
Research Article

Resistance to Chronic Toxoplasma gondii Infection Induced by a DNA Vaccine Expressing GRA16

1State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China
2College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China
3Hunan Entry-Exit Inspection and Quarantine Bureau, Changsha, Hunan 410004, China
4Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu 225009, China

Correspondence should be addressed to Nian-Zhang Zhang; moc.361@919gnahznain

Received 26 May 2017; Accepted 9 July 2017; Published 10 August 2017

Academic Editor: Marlene Benchimol

Copyright © 2017 Ling-Ying Hu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. P. Dubey, Toxoplasmosis of Animals and Humans, CRC Press, Boca Raton, Fla, USA, 2nd edition, 2010.
  2. D. E. Hill, S. Chirukandoth, and J. P. Dubey, “Biology and epidemiology of Toxoplasma gondii in man and animals,” Animal Health Research Reviews, vol. 6, no. 1, pp. 41–61, 2005. View at Publisher · View at Google Scholar
  3. J. P. Dubey, “The history of Toxoplasma gondii—the first 100 years,” The Journal of Eukaryotic Microbiology, vol. 55, no. 6, pp. 467–475, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. P. Zhou, Z. Chen, H.-L. Li et al., “Toxoplasma gondii infection in humans in China,” Parasites & Vectors, vol. 4, article 165, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. T. Štajner, Z. Vasiljević, D. Vujić et al., “Atypical strain of Toxoplasma gondii causing fatal reactivation after hematopoietic stem cell transplantion in a patient with an underlying immunological deficiency,” Journal of Clinical Microbiology, vol. 51, no. 8, pp. 2686–2690, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. J. C. Sepúlveda-Arias, J. E. Gómez-Marin, B. Bobić, C. A. Naranjo-Galvis, and O. Djurković-Djaković, “Toxoplasmosis as a travel risk,” Travel Medicine and Infectious Disease, vol. 12, no. 6, pp. 592–601, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Andiappan, V. Nissapatorn, N. Sawangjaroen et al., “Toxoplasma infection in pregnant women: a current status in Songklanagarind hospital, southern Thailand,” Parasites & Vectors, vol. 7, no. 1, article no. 239, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Reich, M. Ruppenstein, M. D. Becker, and F. Mackensen, “Risk of recurrence of preexisting ocular toxoplasmosis during pregnancy,” Ocular Immunology and Inflammation, vol. 16, pp. 1–6, 2014. View at Google Scholar · View at Scopus
  9. A. Diakoua, E. Papadopoulos, N. Panousis et al., “Toxoplasma gondii and Neospora caninumseroprevalence in dairy sheep and goats mixed stock farming,” Vet Parasitol, vol. 198, pp. 387–390, 2013. View at Publisher · View at Google Scholar
  10. D. E. Hill and J. P. Dubey, “Toxoplasma gondii prevalence in farm animals in the United States,” International Journal for Parasitology, vol. 43, no. 2, pp. 107–113, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. J. M. Unzaga, G. Moré, D. Bacigalupe et al., “Toxoplasma gondii and Neospora caninum infections in goat abortions from Argentina,” Parasitology International, vol. 63, no. 6, pp. 865–867, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. E. A. Innes and A. N. Vermeulen, “Vaccination as a control strategy against the coccidial parasites Eimeria, Toxoplasma and Neospora,” Parasitology, vol. 133, no. 2, pp. S145–S168, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. E. Hiszczyńska-Sawicka, J. M. Gatkowska, M. M. Grzybowski, and H. DŁugońska, “Veterinary vaccines against toxoplasmosis,” Parasitology, vol. 141, no. 11, pp. 1365–1378, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. D. O. Villarreal, K. T. Talbott, D. K. Choo, D. J. Shedlock, and D. B. Weiner, “Synthetic DNA vaccine strategies against persistent viral infections,” Expert Review of Vaccines, vol. 12, no. 5, pp. 537–554, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. N.-Z. Zhang, S.-Y. Huang, D.-H. Zhou et al., “Protective immunity against Toxoplasma gondii induced by DNA immunization with the gene encoding a novel vaccine candidate: calcium-dependent protein kinase 3,” BMC Infectious Diseases, vol. 13, article 512, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. N.-Z. Zhang, M. Wang, Y. Xu, E. Petersen, and X.-Q. Zhu, “Recent advances in developing vaccines against Toxoplasma gondii: an update,” Expert Review of Vaccines, vol. 14, no. 12, pp. 1609–1621, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. V. Feliu, V. Vasseur, H. S. Grover et al., “Location of the CD8 T Cell Epitope within the antigenic precursor determines immunogenicity and protection against the Toxoplasma gondii parasite,” PLoS Pathogens, vol. 9, no. 6, article e1003449, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. N.-Z. Zhang, J. Chen, M. Wang, E. Petersen, and X.-Q. Zhu, “Vaccines against Toxoplasma gondii: new developments and perspectives,” Expert Review of Vaccines, vol. 12, no. 11, pp. 1287–1299, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Chen, Z.-Y. Li, E. Petersen, S.-Y. Huang, D.-H. Zhou, and X.-Q. Zhu, “DNA vaccination with genes encoding Toxoplasma gondii antigens ROP5 and GRA15 induces protective immunity against toxoplasmosis in Kunming mice,” Expert Review of Vaccines, vol. 14, no. 4, pp. 617–624, 2015. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Meng, A. Zhou, G. Lu et al., “DNA prime and peptide boost immunization protocol encoding the Toxoplasma gondii GRA4 induces strong protective immunity in BALB/c mice,” BMC Infectious Diseases, vol. 13, no. 1, article 494, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. E. Hiszczyńska-Sawicka, G. Oledzka, L. Holec-Gasior et al., “Evaluation of immune responses in sheep induced by DNA immunization with genes encoding GRA1, GRA4, GRA6 and GRA7 antigens of Toxoplasma gondii,” Veterinary Parasitology, vol. 177, no. 3-4, pp. 281–289, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Bougdour, I. Tardieux, and M.-A. Hakimi, “Toxoplasma exports dense granule proteins beyond the vacuole to the host cell nucleus and rewires the host genome expression,” Cellular Microbiology, vol. 16, no. 3, pp. 334–343, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Bougdour, E. Durandau, M.-P. Brenier-Pinchart et al., “Host cell subversion by Toxoplasma GRA16, an exported dense granule protein that targets the host cell nucleus and alters gene expression,” Cell Host and Microbe, vol. 13, no. 4, pp. 489–500, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. N.-Z. Zhang, S.-Y. Huang, Y. Xu et al., “Evaluation of immune responses in mice after DNA immunization with putative Toxoplasma gondii calcium-dependent protein kinase 5,” Clinical and Vaccine Immunology, vol. 21, no. 7, pp. 924–929, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. Y. Xu, N. Z. Zhang, Q. D. Tan et al., “Evaluation of immuno-efficacy of a novel DNA vaccine encoding Toxoplasma gondii rhoptry protein 38 (TgROP38) against chronic toxoplasmosis in a murine model,” BMC Infectious Diseases, vol. 14, no. 1, article 525, 2014. View at Publisher · View at Google Scholar
  26. F. Robert-Gangneux and M. Dardé, “Epidemiology of and diagnostic strategies for toxoplasmosis,” Clinical Microbiology Reviews, vol. 25, no. 2, pp. 264–296, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. G.-H. Peng, Z.-G. Yuan, D.-H. Zhou et al., “Toxoplasma gondii microneme protein 6 (MIC6) is a potential vaccine candidate against toxoplasmosis in mice,” Vaccine, vol. 27, no. 47, pp. 6570–6574, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. Z.-G. Yuan, X.-X. Zhang, R.-Q. Lin et al., “Protective effect against toxoplasmosis in mice induced by DNA immunization with gene encoding Toxoplasma gondii ROP18,” Vaccine, vol. 29, no. 38, pp. 6614–6619, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. F. Tan, X. Hu, F.-J. Luo, C.-W. Pan, and X.-G. Chen, “Induction of protective Th1 immune responses in mice by vaccination with recombinant Toxoplasma gondii nucleoside triphosphate hydrolase-II,” Vaccine, vol. 29, no. 15, pp. 2742–2748, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Wang, X.-Y. Yang, N.-Z. Zhang, D.-L. Zhang, and X.-Q. Zhu, “Evaluation of protective immune responses induced by recombinant TrxLp and ENO2 proteins against Toxoplasma gondii infection in BALB/c mice,” BioMed Research International, vol. 2016, Article ID 3571962, 8 pages, 2016. View at Publisher · View at Google Scholar · View at Scopus
  31. M.-H. Bessieres, B. Swierczynski, S. Cassaing et al., “Role of IFN-γ, TNF-α, IL4 and IL 10 in the regulation of experimental Toxoplasma gondii infection,” Journal of Eukaryotic Microbiology, vol. 44, no. 6, p. 87s, 1997. View at Publisher · View at Google Scholar · View at Scopus
  32. R. Liang, J. V. van den Hurk, A. Landi et al., “DNA prime-protein boost strategies protect cattle from bovine viral diarrhea virus type 2 challenge,” Journal of General Virology, vol. 89, no. 2, pp. 453–466, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. E. Y. Denkers and R. T. Gazzinelli, “Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection,” Clinical Microbiology Reviews, vol. 11, no. 4, pp. 569–588, 1998. View at Google Scholar · View at Scopus
  34. L. David Sibley, “Invasion and intracellular survival by protozoan parasites,” Immunological Reviews, vol. 240, no. 1, pp. 72–91, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. R. T. Gazzinelli, F. T. Hakim, S. Hieny, G. M. Shearer, and A. Sher, “Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-γ production and protective immunity induced by an attenuated Toxoplasma gondii vaccine,” Journal of Immunology, vol. 146, no. 1, pp. 286–292, 1991. View at Google Scholar · View at Scopus
  36. P. C. Sayles, G. W. Gibson, and L. L. Johnson, “B cells are essential for vaccination-induced resistance to virulent Toxoplasma gondii,” Infection and Immunity, vol. 68, no. 3, pp. 1026–1033, 2000. View at Publisher · View at Google Scholar · View at Scopus