Postmenopausal Iron Overload Exacerbated Bone Loss by Promoting the Degradation of Type I Collagen

Figure 3

Values of serum iron, TRACP, ALP, β-CTX, and PINP in different groups. Compared with the Normal group, the Fer of the Bone Loss group and Osteoporosis group increased significantly (); the TRF of the Osteoporosis group decreased significantly (). TRACP, ALP, β-CTX, and PINP in Osteoporosis group were significantly upregulated by contrast with Normal group ( or ). PMOP was associated with iron overload and enhanced bone resorption.