Table 6: Multivariate analysis of the nT-staging system.

VariableRegression coefficientStandard errorP valueHR95% CI
LowUp

For OS
 Age (<50 versus ≥50 years).731.258.0052.0771.2533.444
 New T category (nT3 versus nT4).918.263.0002.5041.4964.190
 N category (N0 versus N1 versus N2 versus N3).391.137.0041.4791.1311.934
 Sex (male versus female)−.164.278.556.849.4931.463
 Pathologic type (WHO I versus II-III).397.473.4011.488.5893.757
 Chemotherapy (yes versus no)−.400.483.407.670.2601.728
 Radiation dose (<73.92 versus ≥73.92 Gy)−.202.437.644.817.3471.924
For LRFS
 Age (<50 versus ≥50 years)1.759.583.0035.8061.85318.197
 New T category (nT3 versus nT4)1.141.538.0433.1311.0908.990
 N category (N0 versus N1 versus N2 versus N3)−.218.270.420.804.4741.366
 Sex (male versus female)−.067.587.909.935.2962.956
 Pathologic type (WHO I versus II-III).462.795.5611.587.3347.542
 Chemotherapy (yes versus no).3961.052.7071.486.18911.675
 Radiation dose (<73.92 versus ≥73.92 Gy)−.5481.042.599.578.0754.456
For DMFS
 Age (<50 versus ≥50 years).262.281.3511.300.7492.255
 New T category (nT3 versus nT4).932.281.0012.5391.4634.404
 N category (N0 versus N1 versus N2 versus N3).432.149.0041.5401.1512.061
 Sex (male versus female)−.144.301.633.866.4801.564
 Pathologic type (WHO I versus II-III).220.524.6751.246.4463.480
 Chemotherapy (yes versus no)−.184.612.763.832.2512.759
 Radiation dose (<73.92 versus ≥73.92 Gy)−.056.439.899.946.4002.237
For DFS
 Age (<50 versus ≥50 years).510.230.0261.6661.0622.613
 New T category (nT3 versus nT4).861.231.0002.3651.5043.719
 N category (N0 versus N1 versus N2 versus N3).308.120.0101.3601.0751.721
 Sex (male versus female)−.122.250.626.885.5421.446
 Pathological type (WHO I versus II-III).390.400.3311.476.6743.236
 Chemotherapy (yes versus no)−.349.439.427.705.2981.669
 Radiation dose (<73.92 versus ≥73.92 Gy)−.132.378.727.876.4181.840

HR, hazard ratio; CI, confidence interval.