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BioMed Research International
Volume 2017 (2017), Article ID 1436080, 12 pages
Review Article

Novel Treponema pallidum Recombinant Antigens for Syphilis Diagnostics: Current Status and Future Prospects

Department of Laboratory Diagnostics of Sexually Transmitted Diseases and Dermatoses, State Research Center of Dermatovenereology and Cosmetology, Korolenko Street 3/6, Moscow 107076, Russia

Correspondence should be addressed to Dmitry Deryabin

Received 2 February 2017; Accepted 21 March 2017; Published 24 April 2017

Academic Editor: György Schneider

Copyright © 2017 Aleksey Kubanov et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The recombinant protein technology considerably promoted the development of rapid and accurate treponema-specific laboratory diagnostics of syphilis infection. For the last ten years, the immunodominant recombinant inner membrane lipoproteins are proved to be sensitive and specific antigens for syphilis screening. However, the development of an enlarged T. pallidum antigen panel for diagnostics of early and late syphilis and differentiation of syphilis stages or cured syphilis remains as actual goal of multidisciplinary expertise. Current review revealed novel recombinant antigens: surface-exposed proteins, adhesins, and periplasmic and flagellar proteins, which are promising candidates for the improved syphilis serological diagnostics. The opportunities and limitations of diagnostic usage of these antigens are discussed and the criteria for selection of optimal antigens panel summarized.