Chenodeoxycholic Acid Derivative HS-1200 Inhibits Hepatocarcinogenesis and Improves Liver Function in Diethylnitrosamine-Exposed Rats by Downregulating MTH1

Figure 4

Gross liver examination: (a) control; (b) HS-1200; (c) HCC; (d) HCC + low dose HS-1200; (e) HCC + high dose HS-1200. HCC, hepatocellular carcinoma; HS-1200, N-[(3a,5b,7a)-3,7-dihydroxy-24-oxocholan-24-yl] b-alanine benzyl ester.

(a)

(b)

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(d)

(e)