Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling

Figure 1

Curcumin offers protection against glomerular expansion in diabetic nephropathy. (a) Representative photomicrographs of Periodic Acid-Schiff- (PAS-) stained renal cortical sections from db/m mice, mock-treated db/db mice, and curcumin-treated db/db mice. (b) Glomerular matrix expansion index (GMI) scores calculated from the analysis of 20 glomeruli per mouse. db/m, nondiabetic mice; db/db, diabetic mice (mock-treated); db/db + Cur, db/db mice treated with curcumin at a dose of 200 mg/kg body weight. , compared with the db/m mice; , compared with the mock-treated db/db mice ( per group). Magnification, ×400; scale bar, 20 μm for all micrographs.

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