Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling

Figure 3

Curcumin reduced interleukin-1β (IL-1β) production and NLRP3 inflammasome activity in db/db mice. The expression of NLRP3 protein (a) and cleavage of caspase-1 (b) and IL-1β (c) as determined using Western blot analysis; β-actin was used as the internal loading control. db/m, nondiabetic mice; db/db, diabetic mice (mock-treated); db/db + Cur, db/db mice treated with curcumin at a dose of 200 mg/kg body weight. , compared with the db/m mice (control); , compared with the mock-treated db/db mice ( per group).

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