Association of Platelet Membrane Glycoprotein HPA-2a/b, GP VI T13254C, and GP Ibα VNTR Polymorphisms with Risk of Coronary Artery Disease: A Meta-Analysis
Table 1
Primary characteristics of included studies.
References
Location
Race
Diagnostic criteria
Gene
Age (yrs)
Disease definition
Male (%)
Source of controls
Sample
for HWE
Ca
Co
Ca/Co
Ca/Co
Hato et al. 1997
Japan
2
WHO
1
54.0 ± 5.6
52.3 ± 7.0
MI
86/90
Hospital
88/100
0.340
Murata et al. 1997
Japan
2
No description
1
60.7 ± 8.7
49.1 ± 5.5
CAD
70/91
Hospital
91/105
0.367
Gonzalez-Conejero et al. 1998
Spain
1
WHO
1,3
62.9 ± 11.1
63.7 ± 10.9
ACS
73/73
Hospital
101/101
0.893
Ito et al. 1999
Japan
2
WHO, AHA
1,3
59.3 ± 10.0
51.0 ± 11.2
ACS
85/72
Hospital
158/169
0.912
Zhang et al. 1999
China
2
No description
1
59.2 ± 11.6
56.3 ± 10.7
MI
71/63
Hospital
100/104
0.364
Croft et al. 2001
England
1
WHO
2
61.9 ± 9.2
61.1 ± 9.1
MI
65/63
Hospital
289/292
0.181
Croft et al. 2001
England
1
WHO
2
61.5 ± 9.3
54.4 ± 11.8
MI
73/59
Hospital
236/182
0.972
Reiner et al. 2001
USA
1
No description
1
18–44
18–44
MI
NA
Community
68/346
0.763
Douglas et al. 2002
England
1
No description
3
59.1 ± 9.9
57.0 ± 10.6
MI
90/60
Hospital
88/168
0.952
Rosenberg et al. 2002
Israel
1
No description
1
42.5 ± 4.2
40.6 ± 4.1
MI
100/100
Hospital
100/119
NA
NI et al. 2004
China
2
ACC/AHA
3
60.6 ± 9.0
57.4 ± 11.0
ACS
62/62
Hospital
69/69
0.164
Kou et al. 2004
China
2
Coronarography
2
59.95 ± 6.31
58.76 ± 6.32
CAD
60/57
Hospital
179/164
0.718
Candore et al. 2006
Italy
1
WHO, AHA
1
<46
MI
91/91
Community
105/110
0.671
Aleksic et al. 2000
Croatia
1
Coronarography
1
60.4 ± 9.3
57.5 ± 10.6
CAD
77/53
Hospital
402/202
0.284
Xue et al. 2008
China
2
WHO
1
NA
NA
CAD
NA
Hospital
212/106
NA
Abboud et al. 2010
Tunisia
1
WHO
1
55.5 ± 10.6
54.1 ± 9.4
CAD
72/76
Community
247/316
0.996
Motovska et al. 2010
Czech
1
ACC/ESC
2
47.78 ± 6.13
63.66 ± 9.47
MI
78/34
Hospital
105/132
NA
Musino et al. 2010
Italy
1
WHO
1
47.2
50
MI
86/67
Community
71/150
0.816
Snoep et al. 2010
Holland
1
WHO
2
57 (49–64)
59 (50–66)
MI
100/100
Hospital
545/643
0.480
Shaffer et al. 2011
USA
1
WHO
2
NA
NA
MI
77/77
Community
652/625
NA
Ashavaid et al. 2011
India
3
No description
1,3
58.6 ± 10.4
43.0 ± 11.3
CAD
80/54
Hospital
446/473
0.999
Dogra et al. 2012
India
3
WHO
1
36.4 ± 4.5
31.1 ± 6.0
MI
96/76
Community
184/350
0.340
Chen and Zen 2012
China
2
WHO
1
61.05 ± 10.27
60.74 ± 6.80
MI
79/79
Hospital
86/85
0.543
Kazemi et al. 2012
Iran
1
ACC/ESC
2
46.3 ± 5.2
44.7 ± 6.8
MI
84/41
Hospital
100/100
0.061
Sun et al. 2012
China
2
No description
2
75.96 ± 7.45
71.72 ± 8.31
CAD
68/63
Hospital
246/185
0.852
Zhang et al. 2015
China
2
WHO
1
62.5 ± 11.9
60.1 ± 10.2
ACS
71/59
Hospital
403/500
0.973
Race: (1) Caucasian; (2) East Asians; (3) Indian. Gene: (1) HPA-2; (2) GP VI T13254C; (3) GP Ibα VNTR. Ca, case group; Co, control group. CAD, coronary artery disease; MI, myocardial infarction (acute or chronic); ACS, acute coronary syndrome. Matching with the control; WHO, World Health Organization; AHA, American Heart Association; ESC, European Society of Cardiology.
