Drug Susceptibility of 33 Reference Strains of Slowly Growing Mycobacteria to 19 Antimicrobial Agents

Table 1

The MIC (μg/mL) of 19 antimicrobial agents against 33 reference slowly growing mycobacteria.

(a)

Sp. (international code)	FOX	CFP	CMZ	FEP	RPT	RBT	AZM	CLR	ROX	THI
Mycobacterium avium (DSM44133)	>256	128	>256	>256	4	0.25	4	0.5	1	>256
Mycobacterium intracellulare (ATCC13950)	0.5	8	1	4	<0.03	<0.03	<0.03	0.13	<0.03	<0.25
Mycobacterium shimoidei (ATCC27962)	8	16	4	>256	2	0.06	0.13	<0.03	0.06	>256
Mycobacterium farcinogenes (ATCC35753)	4	16	2	<0.25	<0.03	<0.03	0.13	<0.03	<0.03	2
Mycobacterium simiae (ATCC25275)	>256	256	256	128	16	4	16	1	4	256
Mycobacterium asiaticum (ATCC25276)	2	<0.25	<0.25	1	4	<0.03	0.5	<0.03	0.13	1
Mycobacterium scrofulaceum (ATCC19981)	64	64	32	32	<0.03	<0.03	2	0.06	0.13	<0.25
Mycobacterium szulgai (ATCC35799)	4	2	2	1	<0.03	<0.03	0.13	<0.03	<0.03	256
Mycobacterium africanum (ATCC35711)	64	64	8	256	16	32	32	32	32	>256
Mycobacterium alvei (DSM44176)	16	64	0.5	<0.25	1	0.13	0.06	0.06	<0.03	256
Mycobacterium branderi (ATCC51788)	4	16	1	16	32	0.25	0.25	<0.03	<0.03	>256
Mycobacterium celatum (ATCC44243)	128	128	64	64	32	0.5	1	0.06	0.25	128
Mycobacterium chimaera (DSM44623)	64	32	16	64	16	16	8	0.5	0.5	64
Mycobacterium cosmeticum (DSM44829)	64	>256	8	256	>32	32	2	0.25	1	>256
Mycobacterium duvalii (ATCC43910)	<0.25	16	1	0.5	0.06	<0.03	0.5	0.06	0.13	8
Mycobacterium elephantis (DSM44368)	8	256	2	4	8	2	8	1	4	32
Mycobacterium hassiacum (DSM44199)	128	>256	16	256	32	0.5	<0.03	<0.03	<0.03	>256
Mycobacterium hiberniae (DSM44241)	1	2	<0.25	16	0.25	<0.03	2	0.06	0.13	64
Mycobacterium holsaticum (DSM44478)	1	32	<0.25	0.5	4	1	<0.03	<0.03	<0.03	256
Mycobacterium houstonense (DSM44676)	32	32	64	32	64	>32	32	8	2	64
Mycobacterium kubicae (DSM44627)	64	16	0.5	16	64	>32	2	<0.25	16	256
Mycobacterium lentiflavum (DSM44418)	2	4	4	0.13	0.5	>32	8	2	32	>256
Mycobacterium mageritense (DSM44476)	8	1	0.5	8	32	>32	8	4	16	64
Mycobacterium nonchromogenicum (DSM44164)	2	<0.25	4	<0.25	1	>32	8	2	<0.03	2
Mycobacterium palustre (DSM44572)	<0.25	<0.25	0.5	<0.25	0.06	>32	<0.03	0.5	0.06	4
Mycobacterium parascrofulaceum (DSM44648)	<0.25	<0.25	4	0.25	0.06	8	1	16	<0.03	64
Mycobacterium senuense (DSM44999)	0.5	<0.25	2	<0.25	<0.03	32	1	<0.25	0.06	2
Mycobacterium seoulense (DSM44998)	<0.25	<0.25	4	<0.25	0.5	>32	2	32	<0.03	128
Mycobacterium thermoresistibile (DSM44167)	8	0.25	4	2	2	>32	2	1	1	2
Mycobacterium triplex (DSM44626)	0.25	0.5	<0.25	1	4	>32	1	<0.25	0.13	0.5
Mycobacterium vanbaalenii (DSM7251)	8	0.25	0.5	1	0.06	>32	<0.25	64	1	256
Mycobacterium murale (DSM44340)	0.5	<0.25	0.25	0.25	0.25	>32	<0.25	8	<0.03	2
Mycobacterium gordonae (ATCC14470)	4	0.5	16	0.5	1	>32	8	8	16	128

(b)

Sp. (international code)	DOX	MIN	TIG	MEM	CLO	SMZ	PASI	LNZ	DAP
Mycobacterium avium (DSM44133)	>256	64	32	>256	16	32	32	32	>256
Mycobacterium intracellulare (ATCC13950)	<0.25	<0.25	0.5	0.5	0.13	<0.25	<0.25	<0.06	<0.25
Mycobacterium shimoidei (ATCC27962)	256	64	1	>256	0.13	4	0.5	0.5	64
Mycobacterium farcinogenes (ATCC35753)	0.25	8	<0.03	<0.25	<0.03	1	16	0.25	4
Mycobacterium simiae (ATCC25275)	>256	16	16	>256	<0.03	16	16	32	16
Mycobacterium asiaticum (ATCC25276)	<0.25	0.5	<0.03	<0.25	<0.03	<0.25	2	0.13	<0.25
Mycobacterium scrofulaceum (ATCC19981)	0.25	2	0.5	32	<0.03	16	1	1	2
Mycobacterium szulgai (ATCC35799)	<0.25	<0.25	0.13	0.5	<0.03	<0.25	1	0.13	<0.25
Mycobacterium africanum (ATCC35711)	4	8	0.25	4	32	256	>256	16	4
Mycobacterium alvei (DSM44176)	<0.25	32	<0.03	<0.25	0.5	4	8	16	64
Mycobacterium branderi (ATCC51788)	<0.25	0.5	0.06	0.5	<0.03	0.5	1	<0.06	<0.25
Mycobacterium celatum (ATCC44243)	2	0.5	4	64	<0.03	2	0.5	16	<0.25
Mycobacterium chimaera (DSM44623)	8	32	4	32	0.5	64	>256	16	64
Mycobacterium cosmeticum (DSM44829)	2	128	1	8	32	256	>256	32	256
Mycobacterium duvalii (ATCC43910)	<0.25	16	<0.03	2	1	4	0.5	0.25	8
Mycobacterium elephantis (DSM44368)	<0.25	0.5	<0.03	8	0.13	<0.25	0.5	0.5	0.5
Mycobacterium hassiacum (DSM44199)	<0.25	8	<0.03	256	0.13	8	8	4	16
Mycobacterium hiberniae (DSM44241)	1	8	0.13	4	<0.03	1	8	1	4
Mycobacterium holsaticum (DSM44478)	<0.25	1	0.25	16	0.13	<0.25	1	0.5	0.5
Mycobacterium houstonense (DSM44676)	64	64	16	16	32	256	64	32	256
Mycobacterium kubicae (DSM44627)	>256	16	2	2	32	>256	16	32	>256
Mycobacterium lentiflavum (DSM44418)	>256	128	4	4	4	128	128	4	128
Mycobacterium mageritense (DSM44476)	>256	128	8	8	32	8	128	32	8
Mycobacterium nonchromogenicum (DSM44164)	128	128	16	16	2	4	128	2	4
Mycobacterium palustre (DSM44572)	2	32	0.06	<0.25	0.25	8	32	0.25	8
Mycobacterium parascrofulaceum(DSM44648)	64	32	0.03	<0.25	2	32	32	2	32
Mycobacterium senuense (DSM44999)	1	4	1	1	0.5	4	4	0.5	4
Mycobacterium seoulense (DSM44998)	2	128	8	8	4	8	128	4	8
Mycobacterium thermoresistibile (DSM44167)	256	256	2	2	1	8	256	1	8
Mycobacterium triplex (DSM44626)	256	0.5	0.06	<0.25	0.13	0.5	0.5	0.13	0.5
Mycobacterium vanbaalenii (DSM7251)	8	4	8	8	2	4	4	2	4
Mycobacterium murale (DSM44340)	256	16	0.06	<0.25	0.5	8	16	0.5	8
Mycobacterium gordonae (ATCC14470)	>256	16	16	16	0.5	256	16	0.5	256

Note 1. FOX: cefoxitin; CFP: cefoperazone; CMZ: cefmetazole; FEP: cefepime; RPT: rifapentine; RBT: rifabutin; AZM: azithromycin; CLR: clarithromycin; ROX: roxithromycin; THI: thioacetazone; DOX: doxycycline; MIN: minocycline; TIG: tigecycline; MEM: meropenem; CLO: clofazimine; SMZ: sulfamethoxazole; PASI: pasiniazid; LNZ: linezolid; DAP: dapsone.
Note 2. Bold numbers indicate drug susceptibility. Numbers in bold and cursive indicate intermediate drug susceptibility.