BioMed Research International / 2017 / Article / Tab 1

Review Article

New Insights into the Epigenetics of Hepatocellular Carcinoma

Table 1

Aberrant DNA methylation markers for HCC.

Gene and its locationFunctionMethylation frequency% in adjacent normal tissueMethylation frequency% in HCCRef.

WT1Urogenital development054 [34]
11p13
TIMP3Cell adhesion013 [35]
22q12.3
SOCS-1Cytokine inhibitor0–743–65 [36]
16p13.13
SEMA3BApoptosis83 [37]
3p21.3
RBChromatin structure032 [34]
13q14.2
RASSF1AApoptosis059–75[35, 37]
3p21.3
RaR-BetaRetinoic acid signaling712 [36]
3p24.2
P73Tumor suppressor06 [36]
1p36.32
P53Tumor suppressor014 [34]
17p13.1
P300Growth/cell division065 [34]
22q13.2
P27CDK inhibitor048 [34]
12p13.1
P21CDK inhibitor1063 [34]
6p21.2
P16INK4aCDK inhibitor0–1016–83[35, 36]
9q21.3
P15CDK inhibitor042–47 [36]
18q12.2
P14CDK inhibitor06 [36]
11q13.1
hMLH1Mismatch repair00 [35]
3p21.3
GSTP1Glutathione synthesis0–741–76[35, 36]
11q13
E-CadherinCell adhesion733–67[3436]
16q22.1
E2F-1Transcription factor070 [34]
20q11.22
DAPK1Apoptosis010 [35]
9q21.33
CPS1Urea cycling080 [38]
2q346
COX2Prostaglandin synthesis035–50 [35]
1q31.1
BLUUnknown zinc-finger20 [37]
3q21.3
APCProstaglandin synthesis0–1453–81[35, 36]
5q22.2