Combined Treatment with an Anticoagulant and a Vasodilator Prevents Steroid-Associated Osteonecrosis of Rabbit Femoral Heads by Improving Hypercoagulability

Figure 4

Histological observation. Representative photomicrographs of the subchondral bone (a, b, c, d), the empty lacunae (e, f, g, h), and ratio of empty lacunae (i) of the femoral heads in the four groups. (a, e) The model group showed sparser and more disordered trabecular bone with more empty lacunae, surrounded by fewer marrow cells and more marrow fat cells. In the (b, f) enoxaparin group and (c, g) the ginkgo group, the trabecular bone ranged more regularly. A decreased number of empty lacunae were observed. (d, h) The combination group showed fewer empty lacunae, and the trabecular bone was surrounded with normal marrow. Stain: hematoxylin and eosin; magnification: ×40 (a, b, c, d), ×200 (e, f, g, h). Data are presented as the mean ± SD. ; .