Fibroblast Growth Factor 21 Promotes C2C12 Cells Myogenic Differentiation by Enhancing Cell Cycle Exit

Figure 4

Possible mechanism of FGF21 promoting cell cycle exit and enhancing myogenesis. FGF21 upregulates the expression of P53, P53 increases P21, and then the increased P21 inhibits Cyclin/CDK complexes and arrests cells at G1 phase of cell cycle, and thus myogenic differentiation was enhanced due to cell cycle exit of myoblasts.