BioMed Research International / 2017 / Article / Fig 4

Research Article

Fibroblast Growth Factor 21 Promotes C2C12 Cells Myogenic Differentiation by Enhancing Cell Cycle Exit

Figure 4

Possible mechanism of FGF21 promoting cell cycle exit and enhancing myogenesis. FGF21 upregulates the expression of P53, P53 increases P21, and then the increased P21 inhibits Cyclin/CDK complexes and arrests cells at G1 phase of cell cycle, and thus myogenic differentiation was enhanced due to cell cycle exit of myoblasts.

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.