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BioMed Research International
Volume 2017, Article ID 1681392, 7 pages
https://doi.org/10.1155/2017/1681392
Research Article

The Influence of Different Oregano Species on the Antioxidant Activity Determined Using HPLC Postcolumn DPPH Method and Anticancer Activity of Carvacrol and Rosmarinic Acid

1Department of Drugs Technology and Social Pharmacy, Lithuanian University of Health Sciences, Medical Academy, Kaunas, Lithuania
2Department of Analytical and Toxicological Chemistry, Lithuanian University of Health Sciences, Medical Academy, Kaunas, Lithuania
3Department of Drug Chemistry, Lithuanian University of Health Sciences, Medical Academy, Kaunas, Lithuania

Correspondence should be addressed to Juste Baranauskaite; moc.liamg@etsuj.etiaksuanarab

Received 21 February 2017; Revised 12 April 2017; Accepted 27 August 2017; Published 18 October 2017

Academic Editor: Gail B. Mahady

Copyright © 2017 Juste Baranauskaite et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this study was to evaluate concentration-dependent antioxidant and anticancer activities of CA and RA in ethanol extracts of three different Oregano species (Origanum onites L., Origanum vulgare L., and Origanum vulgare ssp. hirtum). The study revealed the highest RA antioxidant activity in O. vulgare ssp. hirtum ( mmol/g) and the lowest in O. vulgare L. ( mmol/g) (). The highest CA amount was present in O. onites L., which was 1.8 and 4.7 times higher () than in O. vulgare ssp. hirtum and O. vulgare L., respectively. The anticancer activity was evaluated on human glioblastoma (U87) and triple-negative breast cancer (MDA-MB231) cell lines in vitro. RA anticancer activity was negligible. CA and the extracts were about 1.5–2 times more active against MDA-MB231 cell line () compared to U87 cell line. The anticancer activities of three tested extracts were similar against U87 cell line () but they had different activities against MDA-MB231 cell line.