Review Article

Brain-Computer Interface for Clinical Purposes: Cognitive Assessment and Rehabilitation

Table 2

BCI applications to cognitive rehabilitation.

Study (year)Signals/paradigmsSampleMethodOutcome measures

Lim & coll. (2010)Frontal (Fp1 and Fp2) and parietal (Pz) EEG signals, covering theta, alpha, beta 1, and beta 2 EEG waves20 ADHD childrenMathematics and English comprehension questions, with the BCI system monitoring attention levelADHD Rating Scale-IV
Lim & coll. (2012)Frontal EEG signals (Fp1 and Fp2)20 ADHD childrenColour Stroop Task during Calibration. Training game (Cogoland). Mathematics and English worksheetADHD Rating Scale-IV
Lee & coll. (2013)Frontal EEG signals (Fp1 and Fp2)31 healthy elderlyColour Stroop Task during Calibration. BCI system based on a card-pairing memory gameRBANS. Usability and acceptability questionnaire
Toppi & coll. (2014)SMRs2 stroke patientsNF training based on 10 sessions on SMRsEEG data while performing the Sternberg memory task. Behavioral performance at the Sternberg task. Scores at RAVLT and CBTT
Gomez-Pilar & coll. (2014)SMR-EEG40 healthy elderlyNF training consists in imagery motor exercises combined with memory and logical relation tasksLuria–AND test
Burke & coll. (2015)iEEG theta and alpha oscillations14 neurosurgical patients with medication-resistant epilepsyIndividual prestimulus electrode fluctuations used to modulate memory performanceBCI and standard free recall episodic memory task
Lee & coll. (2015)Frontal EEG signals (Fp1 and Fp2)39 healthy Chinese-speaking elderlyColour Stroop Task during Calibration. BCI system based on a card-pairing memory gameRepeatable Battery for the Assessment of Neuropsychological Status (RBANS). Usability and acceptability questionnaire
Rohani & Puthusserypady (2015)P300 ERP6 healthy young participants (24–32 years)Two oddball attention tasks, targeting visual attention and discrimination, performed within a 3D Virtual ClassroomAverage error rate in detecting P300 by the classifier
Salisbury & coll. (2015)EEG (not further specified)A 25-year-old man with spinal cord injuryTraining session with cube rotation and manipulation paradigm presented on a laptop computer, followed by BCI trial (Emotive EEG gaming system)Screening measures related to cognition, psychological disposition and pain
Salisbury & coll. (2016)EEG (not further specified)25 participants (18–64 years) with traumatic or nontraumatic spinal cord injuryTraining session with cube rotation and manipulation paradigm presented on a laptop computer, followed by BCI trial (Emotive EEG gaming system)Screening measures related to cognition, psychological disposition and pain
Gomez-Pilar & coll. (2016)SMR-EEG63 healthy elderlyNF training designed for training motor imagery that implies ERS/ERD of alpha and beta frequency bands in the EEGLuria-AND test
Kim & Lee (2016)SMR and mid-beta waves of Fp1 and Fp220 children with cerebral palsyBCI-FES group versus FES control groupSensorimotor rhythms (SMR) and middle beta waves (M-beta)
Kleih & coll. (2016)P300 ERP5 stroke patients with aphasiaVisual P300 speller paradigm. TAP to predict spelling successBCI usability (visual analog scale) and spelling performance (accuracy)
Rana & coll. (2016)fMRI bold response8 healthy adults (age > 61 years old)rtfMRI approach to train participants to upregulate anterior insula during a facial emotion recognition taskAverage percentage change in the BOLD signal and DCCS scores
Musso & coll. (2017)Auditory ERP20 healthy subjects and 1 aphasic stroke patientWord ERP responses to 6 bisyllabic words recorded with an auditory BCIAverage target and nontarget ERP responses

EEG: electroencephalogram; SMRs: sensory motor rhythm; iEEG: intracranial EEG; ERP: event-related potentials; SMR: sensorimotor rhythms; FES: functional electrical stimulation; fMRI: functional magnetic resonance imaging; ADHD: attention-deficit/hyperactivity disorder; ASD: autism spectrum disorder; RBANS: repeatable battery for the assessment of neuropsychological status; TAP: attention performance test; Luria–AND test: Luria adult neuropsychological diagnosis (AND) test; DDCS: dimensional change card sort; rtfMRI: real-time fMRI; RAVLT: Rey auditory verbal learning test; CBTT: Corsi block tapping test; NF: neurofeedback.