The Role of Adenosine A_2A Receptor, CYP450s, and PPARs in the Regulation of Vascular Tone

Table 1

List of pharmacological drugs commonly used in vascular response investigation.

Class	Reagents	Reagents’ full description
Nonspecific AR agonist	NECA	5′--Ethylcarboxamidoadenosine
Specific AR agonist	CGS 21680	2-p-(2-Carboxyethyl)phenethylamino-5′-N-ethylcarboxamidoadenosine hydrochloride hydrate
AR antagonist	ZM241385	4-(2-[7-Amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-ylamino]ethyl)phenol
	SCH-58261	7-(2-Phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine
A1AR agonist	CCPA	2-Chloro-N6-cyclopentyladenosine
A1AR antagonist	DPCPX	8-Cyclopentyl-1,3-dipropylxanthine
eNOSi	L-NAME	N-Nitroarginine methyl ester
CYP-epoxygenases inhibitor	MS PPOH	N-(Methylsulfonyl)-2-(2-propynyloxy)-benzenehexanamide
CYP-hydroxylase	DDMS	Dibromododecenyl methylsulfimide
Cyclooxygenase inhibitor	Indomethacin
sEH inhibitors	AUDA	12-(3-adamantan-1-yl-ureido)-dodecanoic acid
	t-AUCB	trans-4-[4-(3-Adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid
EET antagonist	14,15-EEZE	14,15-Epoxyeicosa-5(z)-enoic acid
20-HETE inhibitor	HET0016	N-Hydroxy-N′-(4-n-butyl-2-methylphenyl)formamidine
channel blocker	Glibenclamide
Mitochondrial- channel blocker	5-HD	5-Hydroxydecanoate
PPARγ agonist	Rosiglitazone
PPARα antagonist	GW 6471	N-((2S)-2-(((1Z)-1-Methyl-3-oxo-3-(4-(trifluoromethyl)phenyl)prop-1-enyl)amino)-3-(4-(2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy)phenyl)propyl)propanamide