Phylogenetic Diversity in Core Region of Hepatitis C Virus Genotype 1a as a Factor Associated with Fibrosis Severity in HIV-1-Coinfected Patients

Figure 2

Maximum likelihood phylogenetic midpoint routed tree of 335 HCV haplotypes from patients included in the study. Patient-related clusters are identified in different colors with corresponding fibrosis stage between parentheses, as indicated at the top of the figure. Sampling times are coded by symbols (pretreatment: circles; intra- or posttreatment: squares; we coded haplotypes present in both sampling times as triangles). Numbers on branches correspond to relevant bootstrap values. Branch lengths are proportional to the number of nucleotide substitutions per aligned site (bar = 0.01).