New Targets for Zika Virus Determined by Human-Viral Interactomic: A Bioinformatics Approach

Table 3

Membrane receptors as potential targets for ZIKV entry into host cells. Only proteins establishing PPIs with scores ≥ 0.2 are presented (OralInt prediction).

Endocytosis receptors	Type of receptor	Gene name	UniprotKB AC	PPI score		Fold change hNPCs
				E	M
Clathrin-dependent endocytosis	GRPCR	ADRB2	P07550	0.4		3.6
		ADRB3	P13945	0.3	0.4
		ADRB1	P08588	0.2	0.2
		CCR5	P51681	0.2
		CXCR4	P61073	0.2
	LDLR	LDLR	P01130	0.2		1.2
	RTK	EGFR	P00533	0.3
		ERBB4	Q15303	0.2
		FGFR2	P21802	0.2		1.7
		FGFR3	P22607		0.2	−1.5
		FGFR4	P22455	0.2
		MET	P08581	0.4
		PDGFRA	P16234	0.3
	TFR	TFRC	P02786		0.2
	TGFBR	TGFBR2	P37173	0.3	0.3
		TGFBR3	Q03167	0.3
		TGFBR1	P36897	0.2
Clathrin-independent endocytosis	Caveolin	CAV2	P51636	0.2	0.2
		CAV3	P56539	0.2	0.6
	Others	CD81	P60033	0.3	0.4	−1.2
		CLDN1	O95832	0.3	0.3	2.5
		IL2RG	P31785	0.3
		OCLN	Q16625			−1.3
	TIM	HAVCR2	Q8TDQ0	0.4	0.2
	TAM	AXL	P30530	0.2		1.3
	DC-SIGN	CD209	Q9NNX6	0.2	0.2
	L-SIGN	CLEC4M	Q9H2X3	0.2	0.2

Human cortical neural progenitor cells (hNPCs) [56].