New Targets for Zika Virus Determined by Human-Viral Interactomic: A Bioinformatics Approach

Table 4

PPIs established between the different ZIKV proteins and cell receptors and other proteins with an effector or signalling role in the immune response. Only proteins establishing PPIs with scores ≥ 0.2 are presented (OralInt prediction).

Pathway	Gene Name	UniprotKB AC	OralInt score									Fold change hNPCs	Fold change skin 6 h	Fold change skin 24 h
			E	M	NS1	NS2A	NS2B	NS3	NS4A	NS4B	NS5
IFN receptor	IFNAR1	P17181	0.3		0.2	0.2	0.3		0.2		0.3	−1.3	−1.4	−1.3
	IFNAR2	P48551	0.2				0.2				0.2
Toll-like receptor	TLR2	O60603	0.3		0.3	0.3	0.2		0.2	0.4	0.3
	TLR4	O00206	0.3		0.2	0.4	0.3		0.2	0.3	0.2
	TLR5	O60602
	TLR6	Q9Y2C9	0.2	0.2		0.2	0.5		0.4	0.3	0.2
Complement	C2	P06681	0.2	0.3			0.3	0.3	0.2
	C3	P01024				0.3			0.5	0.5	0.4
	C4A	P0C0L4	0.2	0.2			0.2	0.2	0.3	0.3	0.4
	C4B	P0C0L5	0.2	0.2			0.2	0.2		0.3	0.3
	C5	P01031	0.2	0.3	0.3	0.3	0.3	0.4	0.2	0.2
	C6	P13671	0.3	0.7	0.2	0.5	0.5	0.4		0.2	0.2
	C7	P10643	0.3	0.2		0.2	0.2			0.2	0.2
	C8A	P07357		0.3		0.4	0.3	0.3	0.4	0.3	0.3
	C8B	P07358	0.5	0.6	0.5	0.4	0.5	0.6	0.4	0.5	0.6
	C8G	P07360	0.3	0.4	0.2	0.3	0.5	0.3	0.3	0.5	0.3
	C9	P02748		0.2		0.2			0.3	0.0
Cytokines	IL1B	P01584	0.3		0.3	0.4	0.2	0.2	0.2	0.3	0.4		−3.2	−5.3
	IL6	P05231	0.4	0.3	0.4	0.2		0.3	0.2	0.4	0.4		1.1	8.2
	IL17	Q16552	0.4	0.6	0.4	0.2	0.5	0.3	0.4	0.6	0.4
	IL17F	Q96PD4		0.2			0.2		0.2
	IL23A	Q9NPF7		0.2			0.4		0.2
	IL31	Q6EBC2	0.4	0.4	0.3	0.2	0.3	0.3	0.2	0.4	0.4
	CD40L	P29965	0.2			0.3		0.2	0.2	0.2	0.2
	IFNG	P01579	0.2				0.4		0.5		0.2
	TNFA	P01375				0.2							−1.7	−2.1
	IL22	Q9GZX6								0.2
	IL21	Q9HBE4		0.3			0.3		0.3	0.3
	IL33	O95760			0.2						0.2
	IL4	P05112	0.3	0.5	0.4	0.3	0.3	0.2	0.4	0.7	0.2
	IL10	P22301	0.2	0.2	0.2	0.2	0.3	0.2	0.2	0.3	0.2
	IL25	Q9H293	0.3		0.3	0.2	0.2		0.2	0.3	0.3
Chemokines	CCL2 (MCP-1)	P13500
	CCL3 (MIP-1a)	P10147	0.2	0.2	0.2	0.2	0.4	0.2		0.2	0.2		−1.7	−1.4
	CCL4 (MIP-1β)	P13236	0.4	0.2	0.3	0.3	0.5	0.4	0.4	0.4	0.5
	CXCL1 (Gro-a)	P09341	0.6	0.5	0.6	0.6	0.7	0.4	0.5	0.7	0.4
	CXCL2 (Gro-β)	P19875	0.6	0.5	0.6	0.6	0.7	0.4	0.5	0.7	0.4
	CXCL3	P19876	0.6	0.5	0.6	0.6	0.7	0.4	0.5	0.7	0.4
	CXCL8 (IL-8)	P10145	0.2	0.5	0.3	0.3	0.5		0.5	0.5	0.2		−2.8	3.7

Human cortical neural progenitor cells (hNPCs) [56]. Skin (fibroblasts) [17].