Fibrillar Type I Collagen Enhances the Differentiation and Proliferation of Myofibroblasts by Lowering α2β1 Integrin Expression in Cardiac Fibrosis

Figure 4

PP2A activity was regulated by α2β1 integrin on FC. (a) Analysis of PP2A activity in fibroblasts on TC or FC (). (b) Analysis of PP2A activity in shRNA-control or shRNA-β1 integrin transfected fibroblasts on FC (). (c) Analysis of PP2A activity in GD25 α2β1 integrin-null cells or GD25 reconstituted with α2β1 integrin on FC (). (d) Western blots showed the protein levels of α2 and β1 integrin in GD25 without or with α2β1 integrin on FC.

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