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BioMed Research International
Volume 2017 (2017), Article ID 1893520, 7 pages
https://doi.org/10.1155/2017/1893520
Research Article

miR-155 Inhibits Mouse Osteoblast Differentiation by Suppressing SMAD5 Expression

1Department of Respiratory Medicine, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, China
2Endoscopy Center, The China-Japan Hospital of Jilin University, 146 Xiantai Street, Changchun, China
3Department of Pediatrics, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, China
4Cadre’s Ward, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, China

Correspondence should be addressed to Xiaoxue Bai

Received 16 December 2016; Revised 9 March 2017; Accepted 23 March 2017; Published 3 April 2017

Academic Editor: Martin Stoddart

Copyright © 2017 Yue Gu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. F. L. Chau, W. F. Leong, and B. Li, “Signaling pathways governing osteoblast proliferation, differentiation and function,” Histology and Histopathology, vol. 24, no. 12, pp. 1593–1606, 2009. View at Google Scholar · View at Scopus
  2. N. Dirckx, M. Van Hul, and C. Maes, “Osteoblast recruitment to sites of bone formation in skeletal development, homeostasis, and regeneration,” Birth Defects Research Part C—Embryo Today: Reviews, vol. 99, no. 3, pp. 170–191, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. A. R. Amini, C. T. Laurencin, and S. P. Nukavarapu, “Bone tissue engineering: recent advances and challenges,” Critical Reviews in Biomedical Engineering, vol. 40, no. 5, pp. 363–408, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Henkel, M. A. Woodruff, D. R. Epari et al., “Bone regeneration based on tissue engineering conceptions—a 21st century perspective,” Bone Research, vol. 1, no. 3, pp. 216–248, 2013. View at Publisher · View at Google Scholar
  5. G. Chen, C. Deng, and Y.-P. Li, “TGF-β and BMP signaling in osteoblast differentiation and bone formation,” International Journal of Biological Sciences, vol. 8, no. 2, pp. 272–288, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. R. Baron and M. Kneissel, “WNT signaling in bone homeostasis and disease: from human mutations to treatments,” Nature Medicine, vol. 19, no. 2, pp. 179–192, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. G. L. Lin and K. D. Hankenson, “Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation,” Journal of Cellular Biochemistry, vol. 112, no. 12, pp. 3491–3501, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Jonas and E. Izaurralde, “Towards a molecular understanding of microRNA-mediated gene silencing,” Nature Reviews Genetics, vol. 16, no. 7, pp. 421–433, 2015. View at Publisher · View at Google Scholar · View at Scopus
  9. T. Wu, H. Zhou, Y. Hong, J. Li, X. Jiang, and H. Huang, “miR-30 family members negatively regulate osteoblast differentiation,” Journal of Biological Chemistry, vol. 287, no. 10, pp. 7503–7511, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Q. Hassan, J. A. R. Gordon, M. M. Beloti et al., “A network connecting Runx2, SATB2, and the miR-23a~27a~24-2 cluster regulates the osteoblast differentiation program,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 46, pp. 19879–19884, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Eguchi, K. Watanabe, E. S. Hara, M. Ono, T. Kuboki, and S. K. Calderwood, “OstemiR: a novel panel of microRNA biomarkers in osteoblastic and osteocytic differentiation from mesencymal stem cells,” PLoS ONE, vol. 8, no. 3, Article ID e58796, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. Z. Zeng, X. Yin, X. Zhang, D. Jing, and X. Feng, “Cyclic stretch enhances bone morphogenetic protein-2-induced osteoblastic differentiation through the inhibition of Hey1,” International Journal of Molecular Medicine, vol. 36, no. 5, pp. 1273–1281, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. Z. Xiao, L. Cao, Y. Liang et al., “Osteoblast-specific deletion of Pkd2 leads to low-turnover osteopenia and reduced bone marrow adiposity,” PLoS ONE, vol. 9, no. 12, Article ID e114198, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. N. Laxman, C.-J. Rubin, H. Mallmin et al., “Global miRNA expression and correlation with mRNA levels in primary human bone cells,” RNA, vol. 21, no. 8, pp. 1433–1443, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Chen, F. Siegel, S. Kipschull et al., “MiR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit,” Nature Communications, vol. 4, article 1769, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. J. Zhao, Y. Feng, H. Yan et al., “β-arrestin2/miR-155/GSK3β regulates transition of 5′-azacytizine-induced Sca-1-positive cells to cardiomyocytes,” Journal of Cellular and Molecular Medicine, vol. 18, no. 8, pp. 1562–1570, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. L. Wang, H. Zhang, S. Rodriguez et al., “Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB-dependent manner,” Cell Stem Cell, vol. 15, no. 1, pp. 51–65, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Conidi, S. Cazzola, K. Beets et al., “Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo,” Cytokine and Growth Factor Reviews, vol. 22, no. 5-6, pp. 287–300, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. E. Eivers, H. Demagny, and E. M. De Robertis, “Integration of BMP and Wnt signaling via vertebrate Smad1/5/8 and Drosophila Mad,” Cytokine and Growth Factor Reviews, vol. 20, no. 5-6, pp. 357–365, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. P. Nahar-Gohad, N. Gohad, C.-C. Tsai, R. Bordia, and N. Vyavahare, “Rat aortic smooth muscle cells cultured on hydroxyapatite differentiate into osteoblast-like cells via BMP-2–SMAD-5 pathway,” Calcified Tissue International, vol. 96, no. 4, pp. 359–369, 2015. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Dai, Y. Li, H. Zhou, J. Chen, M. Chen, and Z. Xiao, “Genistein promotion of osteogenic differentiation through BMP2/SMAD5/RUNX2 signaling,” International Journal of Biological Sciences, vol. 9, no. 10, pp. 1089–1098, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. J. George, M. G. Lewis, R. Renne, and J. J. Mattapallil, “Suppression of transforming growth factor β receptor 2 and smad5 is associated with high levels of microRNA miR-155 in the oral mucosa during chronic simian immunodeficiency virus infection,” Journal of Virology, vol. 89, no. 5, pp. 2972–2978, 2015. View at Publisher · View at Google Scholar · View at Scopus
  23. D. Rai, S.-W. Kim, M. R. McKeller, P. L. M. Dahia, and R. C. T. Aguiar, “Targeting of SMAD5 links microRNA-155 to the TGF-β pathway and lymphomagenesis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 7, pp. 3111–3116, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. K. Xie, H. Ma, C. Liang et al., “A functional variant in miR-155 regulation region contributes to lung cancer risk and survival,” Oncotarget, vol. 6, no. 40, pp. 42781–42792, 2015. View at Publisher · View at Google Scholar · View at Scopus
  25. Q. Yin, X. Wang, C. Fewell et al., “MicroRNA miR-155 inhibits Bone Morphogenetic Protein (BMP) signaling and BMP-mediated Epstein-Barr virus reactivation,” Journal of Virology, vol. 84, no. 13, pp. 6318–6327, 2010. View at Publisher · View at Google Scholar · View at Scopus