Healing and Antisecretory Effects of Aqueous Extract of Eremomastax speciosa (Acanthaceae) on Unhealed Gastric Ulcers

Figure 1

Macroscopic aspects of “unhealed gastric ulcers” in rats. The red circle indicates the position of an ulcer. (a) Control nonulcerated rats (showing normal healthy mucosa). (b) Ulcerated rats sacrificed on day 5 after ulcer induction (showing well-defined ulcer craters, with raised, inflamed ulcer margins). (c) Ulcerated rats that were given the vehicle and indomethacin for 2 weeks (ulcer craters are reduced due to autohealing). (d–f) Ulcerated rats that were given the extract or sucralfate plus indomethacin for 2 weeks (with significant disappearance of ulcer craters especially at (e) 400 mg/kg extract).

(a) Healthy control

(b) 5th-day control

(c) Vehicle control

(d) Extract at 200 mg/kg

(e) Extract at 400 mg/kg

(f) Sucralfate