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BioMed Research International
Volume 2017, Article ID 1945607, 10 pages
https://doi.org/10.1155/2017/1945607
Research Article

Monitoring the Changes of Material Properties at Bone-Implant Interface during the Healing Process In Vivo: A Viscoelastic Investigation

1School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, 250 Wu-Hsing Street, Taipei, Taiwan
2Department of Molecular Science and Engineering, National Taipei University of Technology, No. 1, Sec. 3, Zhongxiao E. Rd., Taipei, Taiwan
3School of Dentistry, College of Oral Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, Taiwan
4School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, Taiwan

Correspondence should be addressed to Sheng-Wei Feng; wt.ude.umt@iewgnehs

Received 13 November 2016; Revised 20 February 2017; Accepted 26 February 2017; Published 8 March 2017

Academic Editor: Francesco Guido Mangano

Copyright © 2017 Hsiang-Ho Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this study was to monitor the changes of viscoelastic properties at bone-implant interface via resonance frequency analysis (RFA) and the Periotest device during the healing process in an experimental rabbit model. Twenty-four dental implants were inserted into the femoral condyles of rabbits. The animals were sacrificed immediately after implant installation or on day 14, 28, or 56 after surgery. Viscoelastic properties at bone-implant interface were evaluated by measuring the implant stability quotient (ISQ) using RFA and by measuring the Periotest values (PTVs) using the Periotest device. The bone/implant specimens were evaluated histopathologically and histomorphometrically to determine the degree of osseointegration (BIC%). The BIC% values at different time points were then compared with the corresponding ISQ values and PTVs. The mean ISQ value increased gradually and reached on day 56, whereas the mean PTV decreased over time, finally reaching − on day 56. Significant correlations were found between ISQ and BIC% (, ), PTV and BIC% (, ), and ISQ and PTV (, ). These results show that there is a positive correlation between implant stability parameters and peri-implant-bone healing, indicating that the RFA and Periotest are useful for measuring changes of viscoelastic properties at bone-implant interface and are reliable for indirectly predicting the degree of osseointegration.