Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2017, Article ID 1948070, 9 pages
https://doi.org/10.1155/2017/1948070
Research Article

Dynamic Changes of Mitochondrial Fusion and Fission in Brain Injury after Cardiac Arrest in Rats

1Department of Emergency Medicine, The First Affiliated Hospital of Soochow University, Soochow, China
2Institute of Cardiopulmonary Cerebral Resuscitation, Sun Yat-sen University, Guangzhou, China
3Department of Clinical Laboratory Center, The First Affiliated Hospital of Soochow University, Soochow, China
4Department of Emergency Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

Correspondence should be addressed to Peng Wang; moc.liamxof@usysgnawgnep and Zitong Huang; moc.361@tzhxys

Received 17 August 2017; Revised 2 December 2017; Accepted 7 December 2017; Published 28 December 2017

Academic Editor: Sergio Claudio Saccà

Copyright © 2017 Yi Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. G. Geocadin, M. A. Koenig, X. Jia, R. D. Stevens, and M. A. Peberdy, “Management of brain injury after resuscitation from cardiac arrest,” Neurologic Clinics, vol. 26, no. 2, pp. 487–506, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. R. G. Geocadin, M. M. Buitrago, M. T. Torbey, N. Chandra-Strobos, M. A. Williams, and P. W. Kaplan, “Neurologic prognosis and withdrawal of life support after resuscitation from cardiac arrest,” Neurology, vol. 67, no. 1, pp. 105–108, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. Z.-J. Zheng, J. B. Croft, W. H. Giles, and G. A. Mensah, “Sudden cardiac death in the United States, 1989 to 1998,” Circulation, vol. 104, no. 18, pp. 2158–2163, 2001. View at Publisher · View at Google Scholar · View at Scopus
  4. J. P. Nolan, R. W. Neumar, C. Adrie et al., “Post-cardiac arrest syndrome: Epidemiology, pathophysiology, treatment, and prognostication: A Scientific Statement from the International Liaison Committee on Resuscitation; the american heart association emergency cardiovascular care committee; the council on cardiovascular surgery and anesthesia; the council on cardiopulmonary, perioperative, and critical care,” International Emergency Nursing, vol. 18, no. 1, pp. 8–28, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. K. A. Barksdale, E. Perez-Costas, J. C. Gandy, M. Melendez-Ferro, R. C. Roberts, and G. N. Bijur, “Mitochondrial viability in mouse and human postmortem brain,” The FASEB Journal, vol. 24, no. 9, pp. 3590–3599, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. O. Kann and R. Kovacs, “Mitochondria and neuronal activity,” American Journal of Physiology-Cell Physiology, vol. 292, no. 2, pp. 641–657, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Blomgren, C. Zhu, U. Hallin, and H. Hagberg, “Mitochondria and ischemic reperfusion damage in the adult and in the developing brain,” Biochemical and Biophysical Research Communications, vol. 304, no. 3, pp. 551–559, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. D.-H. Cho, T. Nakamura, and S. A. Lipton, “Mitochondrial dynamics in cell death and neurodegeneration,” Cellular and Molecular Life Sciences, vol. 67, no. 20, pp. 3435–3447, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. F. Burte, V. Carelli, P. F. Chinnery, and P. Yu-Wai-Man, “Disturbed mitochondrial dynamics and neurodegenerative disorders,” Nature Reviews Neurology, vol. 11, no. 1, pp. 11–24, 2015. View at Publisher · View at Google Scholar · View at Scopus
  10. V. Parra, H. Verdejo, A. Del Campo et al., “The complex interplay between mitochondrial dynamics and cardiac metabolism,” Journal of Bioenergetics and Biomembranes, vol. 43, no. 1, pp. 47–51, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. S. M. Shenouda, M. E. Widlansky, K. Chen et al., “Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus,” Circulation, vol. 124, no. 4, pp. 444–453, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Zorzano, M. Liesa, and M. Palacín, “Role of mitochondrial dynamics proteins in the pathophysiology of obesity and type 2 diabetes,” The International Journal of Biochemistry & Cell Biology, vol. 41, no. 10, pp. 1846–1854, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Grandemange, S. Herzig, and J.-C. Martinou, “Mitochondrial dynamics and cancer,” Seminars in Cancer Biology, vol. 19, no. 1, pp. 50–56, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. H. Chen and D. C. Chan, “Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases,” Human Molecular Genetics, vol. 18, no. 2, pp. R169–R176, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Li, P. Wang, J. Wei et al., “Inhibition of Drp1 by Mdivi-1 attenuates cerebral ischemic injury via inhibition of the mitochondria-dependent apoptotic pathway after cardiac arrest,” Neuroscience, vol. 311, pp. 67–74, 2015. View at Publisher · View at Google Scholar
  16. T. Drabek, L. M. Foley, A. Janata, J. Stezoski, T. Kevin Hitchens, and M. D. Manole, “Global and regional differences in cerebral blood flow after asphyxial versus ventricular fibrillation cardiac arrest in rats using ASL-MRI,” Resuscitation, vol. 85, no. 7, pp. 964–971, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. R. G. Geocadin, R. Ghodadra, T. Kimura et al., “A novel quantitative EEG injury measure of global cerebral ischemia,” Clinical Neurophysiology, vol. 111, no. 10, pp. 1779–1787, 2000. View at Publisher · View at Google Scholar · View at Scopus
  18. Y.-X. Zhao, M. Cui, S.-F. Chen, Q. Dong, and X.-Y. Liu, “Amelioration of ischemic mitochondrial injury and bax-dependent outer membrane permeabilization by Mdivi-1,” CNS Neuroscience & Therapeutics, vol. 20, no. 6, pp. 528–538, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. J. D. Ly, D. R. Grubb, and A. Lawen, “The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update,” Apoptosis, vol. 8, no. 2, pp. 115–128, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. W. W. Sharp, D. G. Beiser, Y. H. Fang et al., “Inhibition of the mitochondrial fission protein dynamin-related protein 1 improves survival in a murine cardiac arrest model,” Critical Care Medicine, vol. 43, no. 2, pp. e38–e47, 2015. View at Publisher · View at Google Scholar · View at Scopus
  21. C.-R. Chang and C. Blackstone, “Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology,” The Journal of Biological Chemistry, vol. 282, no. 30, pp. 21583–21587, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. J. T. Cribbs and S. Strack, “Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death,” EMBO Reports, vol. 8, no. 10, pp. 939–944, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. R. A. Merrill, R. K. Dagda, A. S. Dickey et al., “Mechanism of neuroprotective mitochondrial remodeling by pka/akap1,” PLoS Biology, vol. 9, no. 4, Article ID e1000612, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. A. B. Knott, G. Perkins, R. Schwarzenbacher, and E. Bossy-Wetzel, “Mitochondrial fragmentation in neurodegeneration,” Nature Reviews Neuroscience, vol. 9, no. 7, pp. 505–518, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. H. Chen, J. M. McCaffery, and D. C. Chan, “Mitochondrial fusion protects against neurodegeneration in the cerebellum,” Cell, vol. 130, no. 3, pp. 548–562, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. H. Bueler, “Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease,” Experimental Neurology, vol. 218, no. 2, pp. 235–246, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. X. Wang, B. Su, H. Lee et al., “Impaired balance of mitochondrial fission and fusion in Alzheimer's disease,” The Journal of Neuroscience, vol. 29, no. 28, pp. 9090–9103, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. U. Shirendeb, A. P. Reddy, M. Manczak et al., “Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage,” Human Molecular Genetics, vol. 20, no. 7, pp. 1438–1455, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. D. C. Chan, “Mitochondrial fusion and fission in mammals,” Annual Review of Cell and Developmental Biology, vol. 22, pp. 79–99, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. F. Legros, A. Lombes, P. Frachon, and M. Rojo, “Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins,” Molecular Biology of the Cell (MBoC), vol. 13, no. 12, pp. 4343–4354, 2002. View at Publisher · View at Google Scholar · View at Scopus