Mesenchymal Stem Cells Attenuate Radiation-Induced Brain Injury by Inhibiting Microglia Pyroptosis

<div>Radiation induced caspase-1-dependent pyroptosis in microglia and increased IL-18 and IL-1<i>β</i> production. (a) 10 Gy radiation promoted the expression of caspase-1 as well as proinflammation cytokine including IL-18 and IL-1<i>β</i> in BV-2 microglia cells at the transcriptional level. (b) Data from laser scanning confocal microscopy demonstrated caspase-1 activation in BV-2 microglia cells exposed to radiation. (c) Increased IL-18 and IL-1<i>β</i> experienced upregulating after radiation. (d) LDH production increased after radiation exposure in BV-2 microglia cells while experiencing decrease after the caspase-1 inhibitor Ac-YVAD was treated. 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BioMed Research International

fig3

Figure 3

Figure 3: Mesenchymal Stem Cells Attenuate Radiation-Induced Brain Injury by Inhibiting Microglia Pyroptosis 