Mesenchymal Stem Cells Attenuate Radiation-Induced Brain Injury by Inhibiting Microglia Pyroptosis

<div>Radiation activated several inflammasomes including NLRP3 which might have taken part in pyroptosis in BV-2 microglia cells exposed to radiation with promoted ROS production. (a) Radiation promoted both AIM2 and NLRP3 increase significantly as well as increasing the expression of ASC, NLRP1, and NLRC4 with no significance. (b) Radiation induced NLRP3 inflammasome activation. (c) After knockdown of NLRP3, LDH production decreased. (d) ROS production increased after radiation. 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BioMed Research International

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Figure 4

Figure 4: Mesenchymal Stem Cells Attenuate Radiation-Induced Brain Injury by Inhibiting Microglia Pyroptosis 