Mesenchymal Stem Cells Attenuate Radiation-Induced Brain Injury by Inhibiting Microglia Pyroptosis

<div>Radiation-induced caspase-1-dependent pyroptosis, increased IL-18 and IL-1<i>β</i> production, and NLRP3 inflammasome activation in microglia were prevented by MSCs. (a) MSCs decreased caspase-1 activation in BV-2 microglia cells exposed to radiation. (b) Increased IL-18 and IL-1<i>β</i> experienced downregulating when coculture was performed after radiation. (c) Increased LDH production in BV-2 microglia cells experienced decrease after MSCs were treated. (d) Radiation-induced NLRP3 inflammasome activation was prevented by MSCs. (e) MSCs prevented ROS production induced by radiation. 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BioMed Research International

fig6

Figure 6

Figure 6: Mesenchymal Stem Cells Attenuate Radiation-Induced Brain Injury by Inhibiting Microglia Pyroptosis 