First-Trimester Crown-Rump Length and Embryonic Volume of Fetuses with Structural Congenital Abnormalities Measured in Virtual Reality: An Observational Study

Table 1

Mean percentage difference and -scores for CRL and EV in both the overall group of structural congenital abnormalities and in the various subgroups.

Variable/congenital abnormality	Mean difference in
		%; (95% CI)		-score; (95% CI)
CRL
Overall	56	−6.43 (−14.55, 1.69)	0.118	−0.46 (−2.21, 1.30)	0.605
Craniofacial	2	−0.60 (−50.36, 49.15)	0.903	−0.05 (−6.25, 6.15)	0.931
Cardiac	5	−5.03 (−16.46, 6.39)	0.288	−1.34 (−2.27, 0.90)	0.296
Skeletal/muscles	8	−3.02 (−18.58, 12.54)	0.660	−0.55 (−2.62, 1.51)	0.547
Gastrointestinal	15	−7.02 (−18.05, 4.02)	0.194	−1.08 (−2.44, 0.28)	0.111
Urogenital	5	−4.98 (−7.87, −2.09)	0.009	−0.64 (−1.04, −0.25)	0.010
Neurological	14	0.12 (−30.53, 30.77)	0.993	1.59 (−5.74, 8.94)	0.646
Hydrops	7	−26.89 (−43.26, −8.51)	0.011	−2.94 (−5.18, −0.71)	0.018
EV
Overall	51	−34.91 (−41.97, −27.85)	<0.001	−1.44 (−1.71, −1.16)	<0.001
Craniofacial	2	−21.22 (−187.3, 144.85)	0.351	−1.00 (−8.73, 6.73)	0.349
Cardiac	5	−31.86 (−56.43, −7.28)	0.023	−1.34 (−2.30, −0.39)	0.017
Skeletal/muscles	6	−26.18 (−60.67, 8.30)	0.108	−0.92 (−2.21, 0.37)	0.127
Gastrointestinal	13	−35.78 (−49.45, −22.11)	<0.001	−1.53 (−2.09, −0.96)	<0.001
Urogenital	4	−16.26 (−25.21, −7.31)	0.010	−0.75 (−1.22, −0.27)	0.016
Neurological	14	−43.24 (−59.20, −27.28)	<0.001	−1.70 (−2.27, −1.13)	<0.001
Hydrops	7	−40.85 (−66.34, −15.36)	0.008	−1.76 (−2.88, −0.64)	0.008

It is for observed mean difference versus 0.