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BioMed Research International
Volume 2017, Article ID 1972429, 7 pages
Research Article

Existence of HbF Enhancer Haplotypes at HBS1L-MYB Intergenic Region in Transfusion-Dependent Saudi β-Thalassemia Patients

1Department of Genetic Research, Institute for Research and Medical Consultation, University of Dammam, Dammam, Saudi Arabia
2King Fahd Hospital of the University, University of Dammam, Dammam, Saudi Arabia
3Maternity and Children’s Hospital, Dammam, Saudi Arabia
4Al-Omran Scientific Chair for Hematological Diseases, King Faisal University, Maternity and Children’s Hospital, Dammam, Saudi Arabia
5College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia
6Center of Excellence in Sickle Cell Disease, Department of Medicine, Boston University School of Medicine, Boston, MA, USA

Correspondence should be addressed to Cyril Cyrus; as.ude.dou@surycc

Received 9 October 2016; Revised 14 December 2016; Accepted 16 January 2017; Published 9 February 2017

Academic Editor: Milton O. Moraes

Copyright © 2017 Cyril Cyrus et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Table S1: Allelic association of 14 SNPs related to BCL11A, HBS1L-MYB, and HBG2 promoter region in patients with β-thalassemia and elevated HbF levels. Table S2: Frequency of haplotypes of SNPs in HBG2, BCL11A, and HBS1L-MYB compared between High HbF and Control cohorts.

  1. Supplementary Material