The Combination of the Tumor Markers Suggests the Histological Diagnosis of Lung Cancer

Table 1

Tumor marker serum levels in 2097 patients with lung disease.

Patients	Lung benign diseases	NSCLC	SCLC	Squamous carcinoma	Adenocarcinoma	Large cell carcinoma
	263	1735	99	399	1311	25
CEA > 5 ng/mL	17 (6.46%)	495 (28.53%)	25 (25.25%)	86 (21.55%)	398 (30.05%)	11 (44%)
Mean ± SD	2.22 ± 1.98	18.43 ± 82.08	13.85 ± 65.23	5.04 ± 14.32	22.58 ± 93.63	14.46 ± 40.22
Median	1.79	2.85	2.85	2.93	2.80	4.64
95th percentile	5.37	71.06	30.66	10.98	92.44	154.41
CA125 > 35 U/mL	35 (13.31%)	317 (18.27%)	29 (29.29%)	80 (20.05%)	234 (17.84%)	3 (12%)
Mean ± SD	20.77 ± 35.45	36.46 ± 151.09	39.77 ± 60.28	26.41 ± 36.29	39.79 ± 172.53	22.19 ± 16.21
Median	11.42	13.71	16.80	15.16	13.28	17.52
95th percentile	67.90	117.04	129.30	79.38	131.32	64.52
SCC > 2 ng/mL	4 (1.52%)	233 (13.43%)	5 (5.05%)	147 (36.68%)	83 (6.33%)	3 (12%)
Mean ± SD	0.69 ± 0.46	1.48 ± 4.22	0.82 ± 1.61	3.40 ± 7.98	0.92 ± 1.65	0.92 ± 0.78
Median	0.56	0.66	0.56	1.38	0.61	0.62
95th percentile	1.62	4.02	2.19	13.75	2.24	2.91
CYFRA21-1 > 3.3 ng/mL	31 (11.78%)	569 (32.8%)	40 (40.40%)	248 (62.15%)	399 (30.43%)	12 (48%)
Mean ± SD	2.25 ± 1.34	4.6 ± 10.51	3.38 ± 2.04	7.72 ± 14.32	3.65 ± 8.95	3.63 ± 1.95
Median	1.99	2.68	2.74	3.95	2.39	3.19
95th percentile	4.35	12.15	7.27	22.14	8.37	7.92
NSE > 25 ng/mL	7 (2.66%)	83 (4.78%)	48 (50%)	30 (7.51%)	45 (3.43%)	8 (32%)
Mean ± SD	14.09 ± 8.08	15.51 ± 10.06	45.48 ± 56.63	16.61 ± 8.23	14.77 ± 7.66	36.73 ± 49.69
Median	12.99	13.87	24.71	14.23	13.72	17.47
95th percentile	19.86	24.76	184.20	29.09	22.80	189.96
ProGRP > 50 pg/mL	22 (8.37%)	140 (8.07%)	81 (81.82%)	33 (8.27%)	99 (7.55%)	8 (32%)
Mean ± SD	31.14 ± 13.29	39 ± 160.28	931.2 ± 1364.54	33.15 ± 20.46	35.46 ± 118.08	318.2 ± 1002.76
Median	31.14	29.45	281.56	29.47	29.39	40.37
95th percentile	55.04	55.97	4451.90	56.36	54.57	3817.24