The Combination of the Tumor Markers Suggests the Histological Diagnosis of Lung Cancer

Table 2

Probability of SCLC according to NSE and/or ProGRP serum levels.

Criteria	Probability (SCLC/total lung cancer)
ProGRP > 50 pg/mL	33.33% (81/243)
ProGRP > 75 pg/mL	71.56% (73/102)
ProGRP > 100 pg/mL	82.5% (66/80)
ProGRP > 125 pg/mL	84.42% (65/77)
ProGRP > 150 pg/mL	85.71% (60/70)
NSE > 25 ng/mL	34.78% (48/138)
NSE > 30 ng/mL	47.72% (42/88)
NSE > 35 ng/mL	55.07% (38/69)
NSE > 40 ng/mL	58.82% (30/51)
NSE > 45 ng/mL	56.81% (25/44)
ProGRP > 100 pg/mL and NSE > 35 ng/mL	92.11% (35/38)