Magnetic Resonance Elastography Shear Wave Velocity Correlates with Liver Fibrosis and Hepatic Venous Pressure Gradient in Adults with Advanced Liver Disease
Table 2
Correlation coefficients (Spearman ) for selected .
MRE shear wave velocity
HVPG
Ishak fibrosis score
sLOXL2
MRE shear wave velocity ()
0.64
0.71
0.82
HVPG ()
0.64
0.53
0.58
Liver biopsy ()
Ishak fibrosis score
0.71
0.53
0.31
Total HAI inflammation score
0.64
0.49
0.36
0.30
% alpha smooth muscle actin (αSMA)
0.74
0.50
0.51
0.08
Selected laboratory studies ()
Platelets
−0.70
−0.72
−0.47
−0.57
Aspartate aminotransferase (AST)
0.74
0.50
0.55
0.70
Alanine aminotransferase (ALT)
0.28
0.13
0.42
0.24
Gamma-glutamyl transferase (GGT)
0.43
0.63
0.56
0.28
Non-invasive fibrosis indices ()
APRI
0.81
0.57
0.57
0.72
FIB-4
0.67
0.66
0.44
0.71
Forns’ index
0.71
0.76
0.44
0.60
Fibroindex
0.75
0.75
0.40
0.80
Serum soluble LOXL2 ()
0.82
0.58
0.31
Liver LOXL2 ()
0.86a
0.69
0.18
0.31
MRE: magnetic resonance elastography; HVPG: hepatic venous pressure gradient; HAI: histologic activity index; APRI: AST/platelet ratio index; LOXL2: lysyl oxidase-like 2. and liver LOXL2 results available for 8 participants. values are indicated as follows: Italics, 0.01–0.05; Underlined, 0.001–<0.01; Bold, <0.001.
