Protection against Blast-Induced Traumatic Brain Injury by Increase in Brain Volume

Figure 2

(a) Microphotographs of NeuN immunoreactivity in frontal cortex. Scale bars: 200 μm (A), 100 μm (B), and 50 μm (C). (b) Quantitative analysis of immunofluorescence density of NeuN in frontal cortex. Density of fluorescence is significantly decreased in both blast groups compared with controls (Con). (). (c) Microphotographs of NeuN immunoreactivity with low and high magnifications in CA1, CA2, and CA3 regions of hippocampus. Scale bars: 200 μm ((A) and (C)) and 100 μm ((B) and (D)). (d) Quantitative analysis of NeuN immunofluorescence density in CA1, CA2, and CA3 regions of hippocampus. Density of fluorescence is significantly decreased in CA1 in both BOP groups. The blast-induced decrease of NeuN immunoreactivity in CA2 and CA3 regions is ameliorated with IJV compression (I-Blast). , control versus blast exposed animals (/group). Note that -axes in (c) and (d) do not cross -axis at zero density.

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