Protection against Blast-Induced Traumatic Brain Injury by Increase in Brain Volume

Figure 4

(a) Microphotographs of 3-NT immunoreactivity in frontal cortex. Scale bars: 100 μm (A) and 50 μm (B). (b) Quantitative analysis of fluorescence density of 3-NT in cortex. The blast-induced increase of 3-NT is prevented by IJV compression. Con, nonexposed control; Blast, animals exposed to blast; and I-Blast, animals with IJV compression exposed to BOP. , control versus Blast (/group); , I-Blast versus Blast (/group). (c) Microphotographs of 3-NT immunoreactivity in CA1, CA2, and CA3 regions of rat hippocampus. Scale bar: 50 μm. (d) Quantitative analysis of fluorescence density of 3-NT in CA1, CA2, and CA3 regions of hippocampus. There was no significant difference of fluorescence density among experimental groups (/group). Note that -axes in (c) and (d) do not cross -axis at zero density.

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