Interleukin-17 Can Induce Osteoarthritis in Rabbit Knee Joints Similar to Hulth’s Method

Figure 4

(a) H&E staining of the synovium shows that the control group displayed appropriate cell distribution and normal thickness at all 5 time points. At 72 h and at 1 week, the 4 experimental groups showed synovial histology results similar to the control group. At 3 weeks and 6 weeks, 3 groups (the Hulth group, the 10-ng group, and the 50-ng group) displayed significantly increased synovial thickness and cell number, while mild synovial hyperplasia was observed in the 1-ng group. At 12 weeks, the thickness of the synovium and the number of cells in the 3 abovementioned groups were further increased; meanwhile, the 1-ng group also exhibited evident synovial hyperplasia and inflammatory cell infiltration. Red arrows indicate synovial hyperplasia and inflammatory cell infiltration. (b) Histological scores of synovium. Compared to the control group, , . Comparing the 3 IL-17 groups to the Hulth group, , .

(a)

(b)