Tumor-Selective Cytotoxicity of Nitidine Results from Its Rapid Accumulation into Mitochondria

Figure 5

Inhibitory effect of short-term treatment with nitidine (NTD), camptothecin (CPT), or topotecan (TPT) in A549 cells measured using the xCELLigence system. Cell growth was assessed with impedance using the xCELLigence system for A549 cells. Cells were treated with 2 or 5 μM of each compound after 18 h preculture (0 h). After 2 h of treatment, wells of the short-term group were washed and replaced with complete medium without compound. Cell growth was then monitored continuously for 118 h.