Prognostic Significance of Preoperative and Postoperative Complement C3 Depletion in Gastric Cancer: A Three-Year Survival Investigation
Table 1
The demographic and baseline characteristics of patients with gastric cancer.
The pooled
CD group
Control group
value
Age, yrs
56.4 ± 12.2
54.5 ± 15.1
57.2 ± 10.9
0.370
≤65
82 (77.4)
20 (66.7)
62 (81.6)
0.084
>65
24 (22.6)
10 (33.3)
14 (18.4)
Gender, male : female
65 : 41
16 : 14
49 : 27
0.376
BMI, kg/m2
21.6 ± 3.3
20.9 ± 2.8
21.8 ± 3.4
0.231
Comorbidity, (%)
HTN
9 (8.5)
3 (10.0)
6 (7.9)
0.710
DM
4 (3.8)
2 (6.7)
2 (2.6)
0.317
Smoke, (%)
26 (24.5)
9 (30.0)
17 (22.4)
0.456
Alcohol abuse, (%)
13 (12.3)
11 (14.5)
2 (6.7)
0.342
ASA, (%)
0.594
I + II
85 (80.2)
23 (76.7)
62 (81.6)
≥III
21 (19.8)
7 (23.3)
14 (18.4)
Albumin level, g/dL
38.1 ± 7.5
37.9 ± 4.6
38.2 ± 8.4
0.880
Operative time, min
278.7 ± 78.4
281.8 ± 71.8
277.4 ± 81.4
0.796
Type of anastomosis, (%)
0.661
Billroth I
2 (1.9)
0
2 (2.6)
Billroth II
11 (10.4)
3 (10.0)
8 (10.5)
Roux-en-Y
51 (48.1)
15 (50.0)
36 (47.4)
Gastrectomy technique, (%)
0.803
Proximal gastrectomy
13 (12.3)
3 (10.0)
10 (13.2)
Distal gastrectomy
45 (42.4)
12 (40.0)
33 (43.4)
Total gastrectomy
48 (45.3)
15 (50.0)
33 (43.4)
Lymphadenectomy, (%)
0.566
8 (7.5)
1 (3.3)
7 (9.2)
76 (71.7)
23 (76.7)
53 (69.7)
22 (20.8)
6 (20.0)
16 (21.1)
Depth of invasion, (%)
0.251
pT1
8 (7.6)
1 (3.3)
7 (9.2)
pT2
11 (10.3)
1 (3.3)
10 (13.1)
pT3
9 (8.5)
2 (6.7)
7 (9.2)
pT4
78 (73.6)
26 (86.7)
52 (68.4)
Lymph nodes retrievals,
39.2 ± 18.8
41.9 ± 18.4
38.1 ± 19.0
Lymph nodes metastases, (%)
0.650
pN0
31 (29.2)
11 (36.7)
21 (27.6)
pN1
14 (13.2)
3 (10.0)
11 (14.5)
pN2
19 (17.9)
4 (13.3)
16 (21.1)
pN3
40 (37.7)
12 (40.0)
28 (36.8)
Histopathological type, (%)
0.978
Well diff.
7 (6.6)
2 (6.7)
5 (6.5)
Moderate diff.
19 (17.9)
5 (16.7)
14 (18.4)
Poor diff.
80 (75.5)
23 (76.6)
57 (75.0)
pTNM Stage, (%)
0.223
I
12 (11.3)
1 (3.3)
11 (14.5)
II
25 (23.6)
10 (33.3)
15 (19.7)
III
55 (51.9)
16 (53.4)
39 (51.3)
IV
14 (13.2)
3 (10.0)
11 (14.5)
Patients were divided into CD group and control group based on baseline levels of C3 (cutoff value, 0.75 mg/mL). Data present with mean ± SD or number (percentage of column). CD, complement depletion; BMI, body mass index; HTN, hypertension; DM, diabetes mellitus; ASA, American Society of Anesthesia; diff., differentiation. plus means extended lymphadenectomy beyond stations during gastrectomy.
