Prognostic Significance of Preoperative and Postoperative Complement C3 Depletion in Gastric Cancer: A Three-Year Survival Investigation

Table 4

Univariate and multivariate analyses for predicative factors of poor prognosis in gastric cancer patients.

Variable	Univariate analysis				Multivariate analysis
		HR	95% CI of HR	value	HR	95% CI of HR	value
Age	−0.212	0.809	0.399–1.642	0.558
Gender	0.230	1.258	0.579–2.735	0.562
BMI	−0.413	0.662	0.285–1.539	0.338
Tumor Heredity	0.435	1.546	0.449–5.318	0.490
HTN	−1.102	0.332	0.045–2.469	0.282
DM	−0.155	0.857	0.110–6.641	0.882
Smoke	0.542	1.720	0.768–3.849	0.187
Alcohol	−0.114	0.893	0.291–2.736	0.842
Baseline C3	0.536	0.709	0.828–3.529	0.148
Postoperative C3	0.833	2.300	1.131–4.677	0.022	2.640	1.263–5.518	0.010
Tumor location	−0.014	0.986	0.883–1.101	0.804
pT stage	1.370	3.934	1.256–12.326	0.019	2.386	0.720–7.911	0.155
pN stage	−2.257	0.105	0.029–0.377	0.001	1.532	0.964–2.433	0.071
pTNM stage	1.622	5.065	2.698–9.509	0.001	1.749	2.024–11.141	0.001
Histology	0.372	1.450	0.760–2.769	0.260
Tumor	0.620	1.860	1.229–2.814	0.003	0.867	0.515–1.462	0.593

Cox regression method was utilized for those analyses, with the following cutoff values for risk factors: age, 65 yrs; BMI, 18.5 kg/m²; tumor heredity, GC family history; HTN, hypertension; DM, diabetes mellitus; C3, 0.75 mg/mL at admission or postoperative day 3; tumor location, up/middle/low 1/3 stomach; TNM stage, I/II versus III/IV; histology, high/moderate/low differentiation; tumor marker, any increased values beyond upper limit of reference range at admission. Multivariate analysis using postoperative C3, pT stage, pN stage, pTNM stage, and tumor marker was performed with Enter mode. makers in digestive malignant diseases, including AFP (0–20 μg/L), CEA (0–5 μg/L), CA125 (0–35 U/mL), CA19-9 (0–35 U/mL), and SCC (0–1.5 μg/L), were measured at admission or follow-up visits.