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BioMed Research International
Volume 2017, Article ID 2317846, 14 pages
Review Article

A Review of the Combination Therapy of Low Frequency Ultrasound with Antibiotics

Center of Medicine Clinical Research, Department of Pharmacy, PLA General Hospital, Beijing, China

Correspondence should be addressed to Lei Xia; moc.361@103_ielaix

Received 31 May 2017; Revised 1 August 2017; Accepted 29 August 2017; Published 16 October 2017

Academic Editor: Konstantinos Anagnostakos

Copyright © 2017 Yun Cai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Single antimicrobial therapy has been unable to resist the global spread of bacterial resistance. Literatures of available in vitro and in vivo studies were reviewed and the results showed that low frequency ultrasound (LFU) has a promising synergistic bactericidal effect with antibiotics against both planktonic and biofilm bacteria. It also can facilitate the release of antibiotics from medical implants. As a noninvasive and targeted therapy, LFU has great potential in treating bacterial infections. However, more in-depth and detailed studies are still needed before LFU is officially applied as a combination therapy in the field of anti-infective treatment.