Activity of Fosfomycin- and Daptomycin-Containing Bone Cement on Selected Bacterial Species Being Associated with Orthopedic Infections

Figure 3

Number of samples with the different growth of bacteria in the nutrient broth after incubation with test specimens of 1.0 g (a, d, g, j, m), 1.5 g (b, e, h, k, n), and 2.0 g fosfomycin (c, f, i, l, o)/0.5 g gentamicin-containing bone cement. Bacteria (Staphylococcus aureus ATCC 29213 (MSSA; (a), (b), (c)), S. aureus ATCC 44300 (MRSA; (d), (e), (f)), S. epidermidis DSM 8913 (g, h, i), Enterococcus faecium DSM 13590 (VRE; (j), (k), (l)), and Escherichia coli DSM 22311 (ESBL:SHV-1; (m), (n), (o))) were added at the beginning in a concentration of 10³ or 10⁶ to 10 ml of nutrient media. All controls (bone cement without antibiotics) showed confluent growth (not shown).

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