Small Molecule Supplements Improve Cultured Megakaryocyte Polyploidization by Modulating Multiple Cell Cycle Regulators

<div>Expression of cell cycle-related proteins and cytoskeletal proteins after RRI and SI treatment. (a) Expression of cyclin B1, cyclin D1 cyclin E1, <i>β</i>-actin, p21, and p53 detected by Q-PCR in MEG-01 cells and MK-PROs. (b) The p53, p21, <i>β</i>-actin, and cyclin B1 expression detected by western blot in MEG-01, UT-7, and MK-PROs. The intensity of each band was digitalized and compared by Image Lab software. 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BioMed Research International

fig4

Figure 4

Figure 4: Small Molecule Supplements Improve Cultured Megakaryocyte Polyploidization by Modulating Multiple Cell Cycle Regulators 