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BioMed Research International
Volume 2017, Article ID 2320932, 10 pages
Research Article

Systems Study on the Antirheumatic Mechanism of Tibetan Medicated-Bath Therapy Using Wuwei-Ganlu-Yaoyu-Keli

1School of National Medicine, Chengdu University of TCM, Chengdu, China
2School of Pharmacy, Second Military Medical University, Shanghai, China
3Department of Mathematics, Logistical Engineering University, Chongqing, China
4Institute of Interdisciplinary Complex Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China
5Tibetan Traditional Medical College, Lhasa, China

Correspondence should be addressed to Jing Zhao; moc.liamg@ennajoahz and Yang Ga; moc.liamtoh@alaggnay

Received 9 December 2016; Revised 22 January 2017; Accepted 30 July 2017; Published 26 September 2017

Academic Editor: Kang Ning

Copyright © 2017 Tianhong Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In clinical practice at Tibetan area of China, Traditional Tibetan Medicine formula Wuwei-Ganlu-Yaoyu-Keli (WGYK) is commonly added in warm water of bath therapy to treat rheumatoid arthritis (RA). However, its mechanism of action is not well interpreted yet. In this paper, we first verify WGYK’s anti-RA effect by an animal experiment. Then, based on gene expression data from microarray experiments, we apply approaches of network pharmacology to further reveal the mechanism of action for WGYK to treat RA by analyzing protein-protein interactions and pathways. This study may facilitate our understanding of anti-RA effect of WGYK from perspective of network pharmacology.