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BioMed Research International
Volume 2017, Article ID 2352874, 7 pages
https://doi.org/10.1155/2017/2352874
Research Article

Genetic Variants in the Promoter Region of miR-10b and the Risk of Breast Cancer

1Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China
2Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, China
3State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, China
4Department of Social Medicine and Health Education, School of Public Health, Nanjing Medical University, Nanjing, China

Correspondence should be addressed to Juncheng Dai; nc.ude.umjn@cjd

Received 1 March 2017; Accepted 14 May 2017; Published 12 June 2017

Academic Editor: Hushan Yang

Copyright © 2017 Jiaping Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Variants in microRNA genes may affect their expression by interfering with the microRNA maturation process and may substantially contribute to the risk of breast cancer. Recent studies have identified miR-10b as an interesting candidate because of its close association with the metastatic behavior of breast cancer. However, the roles of miR-10b-related single nucleotide polymorphisms in breast cancer susceptibility remain unclear. This case-control study evaluated the associations between variants in the upstream transcription regulation region of miR-10b and the risk of breast cancer among Chinese women. Seven potentially functional SNPs were investigated using genotyping assays. The potential biological functions of the identified positive SNPs were further evaluated using in silico databases. We found that rs4078756, which was located at the promoter region of miR-10b, was significantly associated with breast cancer risk (rs4078756 AG/GG versus AA, adjusted odds ratio: 1.17, 95% confidence interval: 1.02–1.35). The other six single nucleotide polymorphisms exhibited negative associations. Based on the in silico prediction, rs4078756 potentially regulated miR-10b expression through promoter activation or repression. These findings indicate that a potentially functional SNP (rs4078756) in the promoter region of miR-10b may contribute to breast cancer susceptibility among Chinese women.