Genetic Variants in the Promoter Region of miR-10b and the Risk of Breast Cancer

Figure 1

SNPs have strong linkage disequilibrium with rs4078756 located on the promoter region of miR-10b. The red solid line region is the promoter of miR-10b identified by Vrba et al. The rs3731795 and rs79025511 SNPs have strong linkage disequilibrium () with rs4078756, and are located on the red dotted line region, which were strongly modified by histone H3K27Ac. These regions were enriched with transcription binding sites and DNase clusters, especially at the location of rs3731795.