Genetic Variants in the Promoter Region of miR-10b and the Risk of Breast Cancer
Table 1
Associations between seven SNPs in the miR-10b gene and breast cancer risk.
SNP
Chr
Position
Location
Cases ,064
Controls ,073
Call rate (%)
MAF (case/control)
OR (95% CI)
rs4078756
2q31.1
177,004,115
11 kb upstream of pre-mir-10b
A/G
540/436/84
582/425/66
97.80
0.285/0.260
0.341
1.17 (1.02–1.35)
0.027
rs1348807
2q31.1
177,005,757
9.3 kb upstream of pre-mir-10b
A/G
403/499/156
391/507/171
97.52
0.383/0.398
0.750
0.91 (0.80–1.03)
0.148
rs10188827
2q31.1
177,007,664
7.5 kb upstream of pre-mir-10b
A/G
514/448/99
502/471/99
97.85
0.304/0.312
0.477
0.92 (0.80–1.05)
0.210
rs6736786
2q31.1
177,008,914
6 kb upstream of pre-mir-10b
A/G
419/495/148
446/495/132
97.89
0.372/0.354
0.79
1.13 (0.99–1.29)
0.066
rs10196832
2q31.1
177,011,655
3.5 kb upstream of pre-mir-10b
A/G
936/127/1
920/143/7
97.89
0.061/0.073
0.502
0.87 (0.68–1.12)
0.281
rs4972806
2q31.1
177,012,578
2.5 kb upstream of pre-mir-10b
A/G
352/512/197
361/529/183
97.85
0.427/0.417
0.706
1.03 (0.91–1.17)
0.643
rs1867863
2q31.1
177,014,970
161 bp upstream of pre-mir-10b
A/C
434/488/140
403/519/151
97.89
0.362/0.383
0.477
0.90 (0.79–1.02)
0.105
Major/minor allele; major homozygote/heterozygote/rare homozygote between cases and controls; minor allele frequency (MAF); values for the Hardy-Weinberger equilibrium (HWE) test; logistic regression analysis with adjustment for age, age at menarche, and menopausal status in the additive model; Chr: chromosome, OR: odds ratio, CI: confidence interval.
