Genetic Variants in the Promoter Region of miR-10b and the Risk of Breast Cancer
Table 2
Associations between rs4078756 in the promoter region of miR-10b and breast cancer risk.
Characteristics
Cases
Controls
OR (95% CI)
AA (%)
AG (%)
GG (%)
AA (%)
AG (%)
GG (%)
Age
<51 years
312 (53.0)
242 (41.1)
35 (5.9)
289 (53.3)
226 (41.7)
27 (5.0)
1.05 (0.86–1.28)
0.648
0.111
≥51 years
228 (48.4)
194 (41.2)
49 (10.4)
293 (55.2)
199 (37.5)
39 (7.3)
1.32 (1.08–1.61)
0.007
Menopausal status
Premenopausal
266 (51.9)
211 (41.1)
36 (7.0)
267 (53.0)
212 (42.1)
25 (5.0)
1.15 (0.93–1.42)
0.197
0.540
Postmenopausal
217 (48.2)
194 (43.1)
39 (8.7)
286 (54.5)
201 (38.3)
38 (7.2)
1.26 (1.03–1.54)
0.028
Age at menarche
<16 years
320 (53.5)
236 (39.5)
42 (7.0)
217 (52.8)
172 (41.9)
22 (5.4)
1.03 (0.84–1.26)
0.799
0.115
≥16 years
211 (47.5)
192 (43.2)
41 (9.2)
363 (55.0)
253 (38.3)
44 (6.7)
1.29 (1.06–1.56)
0.010
Age at first live birth
<24 years
119 (49.6)
104 (43.3)
17 (7.1)
204 (55.0)
140 (37.7)
27 (7.3)
1.18 (0.90–1.53)
0.229
0.831
≥24 years
392 (52.0)
301 (39.9)
61 (8.1)
358 (53.4)
276 (41.1)
37 (5.5)
1.14 (0.96–1.36)
0.141
ER status
Positive
237 (48.6)
211 (43.2)
40 (8.2)
1.27 (1.07–1.52)
0.008
0.713
Negative
194 (51.5)
146 (38.7)
37 (9.8)
1.21 (1.0–1.46)
0.055
PR status
Positive
237 (46.9)
223 (44.2)
45 (8.9)
1.34 (1.12–1.60)
0.001
0.204
Negative
192 (53.3)
136 (37.8)
32 (8.9)
1.13 (0.93–1.37)
0.235
Per-allele odds ratio (OR) and 95% confidence interval (CI) adjusted for age, age at menarche, and menopausal status where appropriate; value for the heterogeneity test; ER: estrogen receptor; PR: progesterone receptor.
