Prediction and Validation of Hub Genes Associated with Colorectal Cancer by Integrating PPI Network and Gene Expression Data

Figure 6

Highly interconnected region form four best subnets among the 1335 DEGs and integrated centralities based analysis of subnet. Green color indicates downregulated genes, while red color indicates upregulated genes; the label size represents the level of degree. (a–d) subnet 1, subnet 2, subnet 3, and subnet 4, respectively. (e-f) Comparisons of MCODE_score and degree centrality among the four subnets. There were significant differences in MCODE_score and degree distribution among each subnet.

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