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BioMed Research International
Volume 2017, Article ID 2432957, 10 pages
https://doi.org/10.1155/2017/2432957
Research Article

Copy Number Variations in Candidate Genes and Intergenic Regions Affect Body Mass Index and Abdominal Obesity in Mexican Children

1Laboratorio de Investigación en Epidemiología Clínica y Molecular, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, 39089 Chilpancingo, GRO, Mexico
2Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades “Bernardo Sepúlveda”, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, 06725 Ciudad de México, Mexico
3Centro de Investigación sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, 62100 Cuernavaca, MOR, Mexico
4CNRS-UMR8199, Lille Pasteur Institute, Lille, France
5Lille University, Lille, France
6European Genomic Institute for Diabetes (EGID), 3508 Lille, France
7Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK
8Laboratorio de Genómica y Biología Molecular, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, 39089 Chilpancingo, GRO, Mexico

Correspondence should be addressed to Miguel Cruz; moc.oohay@lzurcm

Received 6 November 2016; Revised 26 January 2017; Accepted 6 February 2017; Published 27 March 2017

Academic Editor: Sarah H. Elsea

Copyright © 2017 Diana Lizzete Antúnez-Ortiz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Table S1 shows the significant differences in CNV frequency between children with obesity compared with that in normal weight children for 3 of the 6 intragenic regions and 3 of the 4 intergenic regions tested. For ARHGEF4, we found that children with obesity more frequently showed gains (22.6%) as also observed for CPXCR1 (49.2%), whereas for INS losses occurred most frequently in obese children (25.7%). Regarding intergenic regions, it was found that, in children with obesity, gains occurred more frequently at the positions 12q15c (43.5%), 15q21.1a (37.9%), and 22q11.21d (38.1%) compared with those in children of normal weight.

  1. Supplementary Material